POISONING AND DRUG OVERDOSAGE Department of Internal Medicine WAN Weiguo
POISONING AND DRUG OVERDOSAGE Department of Internal Medicine WAN Weiguo
General Info All chemicals have potential to be poisons if given a large enoug h dose Poisoning occurs when exposure to a substance adversely affects function of any organ system a3 factors toxicants i dose-related hazards to the body
General Info All chemicals have potential to be poisons if given a large enough dose Poisoning occurs when exposure to a substance adversely affects function of any organ system 3 factors toxicants ; dose-related ; hazards to the body
Definition Development of dose-related adverse effects Following exposure to chemicals, drugs, or other xenobiotics
Definition: Development of dose-related adverse effects following exposure to chemicals,drugs,or other xenobiotics
classification Chemicals fron: industrial、 medicine、 pesticide、 plants、 animals ● Organ or tissue involved: cardiovascular、 respiratory, nerve, liver, kidney blood Causation: occupational, daily life Onset: acute, subacute, chronic
classification Chemicals from：industrial、medicine、 pesticide、 plants、 animals Organ or tissue involved：cardiovascular、 respiratory, nerve, liver, kidney, blood Causation：occupational, daily life Onset：acute, subacute, chronic
Epidemiology More than 5 million toxic exposures reported in 2006 US each year Over half were children 6 yo Poisoning third leading cause of death from 1985-1995 Most are acute and accidental 5% require hospitalization Incidence of toxin related deaths increase 300%, Mortality 0.4%
Epidemiology More than 5 million toxic exposures reported in 2006 US each year Over half were children < 6 yo Poisoning third leading cause of death from 1985-1995 Most are acute and accidental 5% require hospitalization Incidence of toxin related deaths increase 300%, Mortality 0.4%