RHEUMATOID ARTHRITIS Lindi Jiang, Xiaomin Dai Zhongshan Hospital Fudan University ianglindi@medmail.com.cn dai xiaomin @zs-hospitalsh cn
Lindi Jiang，Xiaomin Dai Zhongshan Hospital Fudan University jianglindi@medmail.com.cn dai.xiaomin@zs-hospital.sh.cn RHEUMATOID ARTHRITIS
Introduction aa chronic multisystem disease of unknown cause persistent inflammatory synovitis, usually involving peripheral Joints in a symmetric distribution 8% Ra patients with positive rheumatoid factor Pathologic change: chronic synovitis with pannus formation cartilage damage and bone erosion are the hallmarks of the disease
Introduction a chronic multisystem disease of unknown cause. persistent inflammatory synovitis, usually involving peripheral joints in a symmetric distribution. 68% RA patients with positive Rheumatoid factor Pathologic change: chronic synovitis with pannus formation cartilage damage and bone erosion are the hallmarks of the disease
Epidemiology and Genetics The prevalence of ra in China is approximately 0.3%o of the population a women are affected approximately three times more often than men 80% of all patients develop the disease between the ages of 35 and 50
Epidemiology and Genetics The prevalence of RA in China is approximately 0.3% of the population women are affected approximately three times more often than men 80% of all patients develop the disease between the ages of 35 and 50
Epidemiology and Genetics a Family studies indicate a genetic predisposition a The class Ii major histocompatibility complex allele HLA-DR4 (DRB1* 0401) and related alleles are known to be major genetic risk factors for ra
Epidemiology and Genetics Family studies indicate a genetic predisposition. The class II major histocompatibility complex allele HLA-DR4 (DRß1*0401) and related alleles are known to be major genetic risk factors for RA
Environmental factors also play a role in the etiology of the disease, such as stress, humidity, cold infectious agent and cigarette smoking It has been suggested that developed ra might be a response to an incentive in a genetically susceptible host
Environmental factors also play a role in the etiology of the disease，such as stress, humidity, cold, infectious agent and cigarette smoking It has been suggested that developed RA might be a response to an incentive in a genetically susceptible host