Components of a polypeptide chainApolypeptide chain consists ofa constant backbone andvariable side chains (shown in green)
A polypeptide chain consists of a constant backbone and variable side chains (shown in green). Components of a polypeptide chain
ThePeptideBondUsuallyfound in thetrans configurationHas partial double bond character - shorter than a typical singlebond but longer than a double bondDue to the double bond character, the six atoms of the peptidebond group are always planar!
The Peptide Bond Usually found in the trans configuration Has partial double bond character - shorter than a typical single bond but longer than a double bond Due to the double bond character, the six atoms of the peptide bond group are always planar!
ThePeptideBondIsRigidandPlanar3covalentbondsseparatetheαcarbonsofadjacentaminoacidresidues:Cα-C-N-Cαresonancebetweenthecarbonyloxygenandtheamidenitrogenchargeissharedpartial negative charge and partial positive charge sets upasmallelectricdipole
charge is shared
Peptide C-N Bonds CannotRotate Freely6atomsofthepeptidegrouplieinasingleplanepartial double-bondcharacterof CNpeptidebondpreventsrotation,limitingrangeofconformationsCarboxylterminus14632AAminoterminusN-CC-NC-C(b)Thereislimitstotherangeof conformationthatproteinscantake
There is limits to the range of conformation that proteins can take
The Sequence of Amino Acids in a Proteinisauniquecharacteristicofeveryproteinis encodedbythenucleotidesequenceof DNAisthusaformofgeneticinformationisread fromthe amino terminus tothe carboxyl terminus
The Sequence of Amino Acids in a Protein is a unique characteristic of every protein is encoded by the nucleotide sequence of DNA is thus a form of genetic information is read from the amino terminus to the carboxyl terminus