The Three-dimentionalStructure of Proteins
The Three-dimentional Structure of Proteins
KeyPrinciplesProtein structures are stabilized by non-covalent interactionsandforces.Protein segmentscanadoptregular secondary structuressuch as the alpha helix and the beta conformation.Tertiary structures is determined by amino acid sequenceThe3Dstructuresofproteinscanbedetermined
Key Principles Protein structures are stabilized by non-covalent interactions and forces. Protein segments can adopt regular secondary structures such as the alpha helix and the beta conformation. Tertiary structures is determined by amino acid sequence. The 3D structures of proteins can be determined
The RelationshipbetweenProteinStructure and Functioninprinciple,proteinscanassumeanuncountablenumberofspecialarrangements,orconformationschemicalorstructuralfunctionsrelatetouniquethree-dimensionalstructures
OverviewofProtein StructureProtein Conformationslimitednumberofconformationspredominateunderbiologicalconditionsconformations=thermodynamicallythemoststable,thatis,lowestfreeenergy (G)native = proteins in any functional, foldedconformations
Overview of Protein Structure
A Protein's Conformation Is Stabilized LargelybyWeakInteractionsstability=tendencyofaproteintomaintainanativeconformationunfoldedproteinshavehighconformationalentropychemical interactionsstabilizenativeconformations=strongdisulfide(covalent)bondsareuncommon-weak (noncovalent)interactionsandforcesarenumerous.hydrogenbonds.hydrophobiceffect.ionicinteractions