Central dogma replication transcription translation DNA→RA→ Protein RNA replication reverse transcription
Central dogma replication DNA reverse transcription RNA Protein transcription translation RNA replication
DNA replication A reaction in which daughter DNAs are synthesized using the parental DNAs as the template. Genetic information is transmitted in high fidelity replication Complete and accurate Parental DNA Daughter DNA
DNA replication replication Parental DNA Daughter DNA A reaction in which daughter DNAs are synthesized using the parental DNAs as the template. Genetic information is transmitted in high fidelity Complete and accurate
The overall DNA synthesis reaction: (dNMP)n dNTP(dNMP)n+1 PPi DNA strand substrate elongated DNA strand Replication of both daughter strands proceeds by addition of nucleotide monomers in the 5'to 3'direction Template DNA 5 PP. DNA polymerase B1'B2'B3'B4'B5 B1'B2'B3'B4' B5 61B2B3 0H+ OH ...P attack OH 5→3 Replicated DNA Phosphodiester bond formation
The overall DNA synthesis reaction: (dNMP)n + dNTP (dNMP)n+1 + PPi DNA strand substrate elongated DNA strand Phosphodiester bond formation attack Replication of both daughter strands proceeds by addition of nucleotide monomers in the 5’ to 3’ direction
Section1 Basic concepts and general principles of DNA replication
Section1 Basic concepts and general principles of DNA replication
1.General principles of DNA replication DNA replication is a process of Semi-conservative replication Semi-discontinuous replication Bidirectional replication High fidelity replication
§ 1. General principles of DNA replication DNA replication is a process of ⚫ Semi-conservative replication ⚫ Semi-discontinuous replication ⚫ Bidirectional replication ⚫ High fidelity replication