复旦大学附属中山医院 呼吸科暨呼吸病研究所 上海市重点学 Pulmonary Tuberculosis Jing ZHANG(张静),MD,PhD zhang jing @zs-hospital shcn Department of Pulmonary medicine Zhongshan Hospital Fudan University MBBS project, Zhongshan Hospital
MBBS project, Zhongshan Hospital Pulmonary Tuberculosis Jing ZHANG (张静), MD, PhD zhang.jing@zs-hospital.sh.cn Department of Pulmonary Medicine Zhongshan Hospital Fudan University
OUTLINE ° Etiologic agents Epidemiology Pathogenesis and immunity Clinical manifestation Lab investigations and diagnosis Treatment (drugs, regimen, drug-resistant TB Prevention(vaccine preventive treatment, disease control) MBBS project, Zhongshan Hospital
MBBS project, Zhongshan Hospital OUTLINE • Etiologic agents • Epidemiology • Pathogenesis and immunity • Clinical manifestation • Lab investigations and diagnosis • Treatment (drugs, regimen, drug-resistant TB) • Prevention (vaccine, preventive treatment, disease control)
Robert Koch Discovers Mycobacterium(1882)
MBBS project, Zhongshan Hospital Dr.T.V.R ao Robert Koch Discovers Mycobacterium (1882)
Etiology · Mycobacteria M. tuberculosis &m, bovis M tuberculosis-90% of human disease M. avium, M intracellulare in AIDs -Atypical TB Bacilli aerobic, non motile, no toxins no spore. Mycolic acid wax in cell wall Carbol dye-Acid alcohol fast(AFB) MBBS project, Zhongshan Hospital
MBBS project, Zhongshan Hospital Etiology • Mycobacteria — M. tuberculosis & M. bovis — M. tuberculosis-90% of human disease — M. avium, M.intracellulare in AIDS - Atypical TB • Bacilli, aerobic, non motile, no toxins, no spore. • Mycolic acid wax in cell wall • Carbol dye - Acid & alcohol fast (AFB)
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