复旦大学附属中山医院 呼吸科暨呼吸病研究所 上海市重点学 Chronic obstructive Pulmonary Disease Jing ZHANG(张静),MD,PhD zhang jing@zs-hospitalshcn Department of Pulmonary Medicine Zhongshan Hospital Fudan University MBBS project, Zhongshan Hospital
MBBS project, Zhongshan Hospital Chronic Obstructive Pulmonary Disease Jing ZHANG (张静), MD, PhD zhang.jing@zs-hospital.sh.cn Department of Pulmonary Medicine Zhongshan Hospital Fudan University
OUTLINE Definition of coPd ° Epidemiology Etiology and risk factors Pathophysiology mechanisms Clinical manifestation How to make the diagnosis and assess the severity of disease Management of stable copd and AEcoPD Prevention MBBS project, Zhongshan Hospital
MBBS project, Zhongshan Hospital OUTLINE • Definition of COPD • Epidemiology • Etiology and risk factors • Pathophysiology mechanisms • Clinical manifestation • How to make the diagnosis and assess the severity of disease • Management of stable COPD and AECOPD • Prevention
GOLD Global Initiative for chronic Obstructive Lung NITIA Disease Global strategy for Diagnosis, Management and Prevention of copd CTIVE MBBS project, Zhongshan Hospital
MBBS project, Zhongshan Hospital GOLD • Global Initiative for Chronic Obstructive Lung Disease • Global Strategy for Diagnosis, Management and Prevention of COPD
Definition COPD is a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients Its pulmonary component is characterized by airflow limitation that is not fully reversible The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases MBBS project, Zhongshan Hospital
MBBS project, Zhongshan Hospital Definition • COPD is a preventable and treatable disease with some significant extrapulmonary effects that may contribute to the severity in individual patients. • Its pulmonary component is characterized by airflow limitation that is not fully reversible. • The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lung to noxious particles or gases
Epidemiology COPD is a leading cause of morbidity and mortality worldwide and results in an economic and social burden that is both substantial and Increasing 1990 2020 Ischemic heart disease Cerebrovascular disease 一 COPD 263 Lower respiratory infection Lung cancer 10 Road traffic accidents Tuberculosis 2345678 Stomach cancer 14
Epidemiology • COPD is a leading cause of morbidity and mortality worldwide and results in an economic and social burden that is both substantial and increasing. 1990 1 2 6 3 10 9 7 14 Ischemic heart disease Cerebrovascular disease COPD Lower respiratory infection Lung cancer Road traffic accidents Tuberculosis Stomach cancer 2020 1 2 3 4 5 6 7 8