3 wobble 5 tRNA mRNA 5' AT 3
U wobble
Wobble hypothesis 1 2 3 G C U G C C mRNA: 5'-G-C-A--31 tRNA:3 -C-G-I-一5 Anticodon of ala 321 from yeast The first base of anticodon is key to determine the number of codons it can identify
The first base of anticodon is key to determine the number of codons it can identify. mRNA: 5’ —G—C—A——3’ tRNA ： 3’ —C—G—I——5’ G C U G C C Wobble hypothesis 1 2 3 3 2 1 Anticodon of ala from yeast
Diagram of wobble base pairing 5'base on anticodon 3'base on codon A U G G (c U A G I A
Diagram of wobble base pairing A U C G 5’base on anticodon 3’base on codon G U C U A G I U C A
Activated amino acid-aminoacyl- tRNA Aminoacyl-tRNA:gly-tRNAsly Initiation aminoacyl-tRNA:(f)met-tRNA(f)met Elongation aminoacyl-tRNA:ala-tRNA ala
● Activated amino acid —aminoacyltRNA Aminoacyl-tRNA：gly-tRNAgly Initiation aminoacyl-tRNA： (f)met-tRNAi (f)met Elongation aminoacyl-tRNA： ala-tRNAe ala
S 1.3 Protein synthesis site: (Ribosomes) 21 nm
§1.3 Protein synthesis site: （Ribosomes）