Water soluble bases, for example, PEG, which dissolve in the anorectal fluids release for absorption both water-soluble and oil-soluble drugs. Naturally, the more drug a base contains the more drug will be available for potential absorption
- Water soluble bases, for example, PEG, which dissolve in the anorectal fluids, release for absorption both water-soluble and oil-soluble drugs. - Naturally, the more drug a base contains, the more drug will be available for potential absorption
Particle size For drugs present in a suppository in the undissolved state, the size of the drug particle will influence its rate of dissolution and its availability for absorption The smaller the particle size, the more readily the dissolution of the particle and the greater the chance for rapid absorption
◼ Particle size - For drugs present in a suppository in the undissolved state, the size of the drug particle will influence its rate of dissolution and its availability for absorption. - The smaller the particle size, the more readily the dissolution of the particle and the greater the chance for rapid absorption
Nature of the base The possiblity of chemical and/or physical interactions between the medicinal agent and the suppository base, which could affect the stability and or bioavailability of the drug. If the base is irritating to the mucous membranes of the rectum, it may initiate a colonic response and prompt a bowel movement, negating the prospect of complete drug release and absorption
◼ Nature of the base - The possiblity of chemical and/or physical interactions between the medicinal agent and the suppository base, which could affect the stability and/or bioavailability of the drug. - If the base is irritating to the mucous membranes of the rectum, it may initiate a colonic response and prompt a bowel movement, negating the prospect of complete drug release and absorption
3. Suppository bases One of the first requisites for a suppository base is that it remains solid at room temperature but softens, melts or dissolves readily at body temperature so that the drug it contains may be made fully available soon after insertion
3. Suppository bases One of the first requisites for a suppository base is that ◼ it remains solid at room temperature ◼ but softens, melts or dissolves readily at body temperature ◼ so that the drug it contains may be made fully available soon after insertion
Classification of suppository bases 1) Fatty or oleaginous base Cocoa butter is defined as the fat obtained from the roasted seed of Theobroma cacao At room temperature it is a yellowish, white solid having a faint, agreeable chocolate-like odor
Classification of suppository bases 1) Fatty or oleaginous base ◼ Cocoa butter - is defined as the fat obtained from the roasted seed of Theobroma cacao. - At room temperature it is a yellowish, white solid having a faint, agreeable chocolate-like odor