★Chapter5Diseases of Urinary systemDAIMPathogenesis>Immune-mediated glomerulonephropathyischaracterizedbydepositionor insituformationof immunecomplexesin the glomerular capillary wall, which then inciteinfl淋巴因子溶酶体、超氧阴离子自由基和过氧左：正常肾小球（毛细血管）右：肾炎病变肾小球（毛细血管）：1.上皮细胞2.基底膜3.内皮细胞4.系膜细胞5.嗜中性粒细胞6.免疫复合物Guangdong OceanUniversity
6 uPathogenesis Ø Immune-mediated glomerulonephropathy is characterized by deposition or in situ formation of immune complexes in the glomerular capillary wall, which then incite inflammatory changes. Chapter 5 Diseases of Urinary system 正常肾小球(毛细血管) ：肾炎病变肾小球(毛细血管) ：1.上皮细 胞 2.基底膜 3.内皮细胞 4.系膜细胞 5.嗜中性粒细胞 6.免疫复合物 淋巴因子、 溶酶体、超 氧阴离子自 由基和过氧 化物
★Chapter5Diseases ofUrinary systemVIMPathogenesis> Familial glomerulopathies肾小球疾病 as a primary cause ofchronickidney diseasehavebeenreported in severalbreeds of dogs.These arenot immunecomplexdiseases, although some are characterized byproteinuria and associated clinical abnormalities thatresemblethosecaused byimmune-mediatedglomerulonephropathy.In one study of dogs, the mean age of presentation for glomerulonephritis was 4-8yr;55% weremales.Guangdong Ocean University
7 uPathogenesis Ø Familial glomerulopathies肾小球疾病 as a primary cause of chronic kidney disease have been reported in several breeds of dogs. These are not immune complex diseases, although some are characterized by proteinuria and associated clinical abnormalities that resemble those caused by immune-mediated glomerulonephropathy. Ø In one study of dogs, the mean age of presentation for glomerulonephritis was 4-8 yr; 55% were males. Chapter 5 Diseases of Urinary system
Chapter5Diseases ofUrinarysystemDAIMClinical Findings>Glomerulopathy often leads to proteinuria (primarilyalbuminuria)and canproduce hypoproteinemia, ascites, dyspnea (due to pleural effusion orpulmonary edema), and/or peripheral edema, which may be referred to asthe nephrotic syndrome.Protein wasting can produce preferential loss ofleanbodymass thatmaybeapparent oncareful physical examination.Systemichypertensionmaybemoreprevalent inproteinuricchronickidney disease and may observed at any stage.Proteinuria may result in loss of antithrombin抗凝血酶 IIthrough the glomerular basementmembrane, leading to a hypercoagulable state高凝状态 in dogs,generally when plasmaalbumin levels are ≤1.0 g/dLGuangdong Ocean University
8 uClinical Findings Ø Glomerulopathy often leads to proteinuria (primarily albuminuria) and can produce hypoproteinemia, ascites, dyspnea (due to pleural effusion or pulmonary edema), and/or peripheral edema, which may be referred to as the nephrotic syndrome. Protein wasting can produce preferential loss of lean body mass that may be apparent on careful physical examination. Systemic hypertension may be more prevalent in proteinuric chronic kidney disease and may observed at any stage. Ø Proteinuria may result in loss of antithrombin抗凝血酶 III through the glomerular basement membrane, leading to a 高凝状态 in dogs, generally when plasma albumin levels are ≤1.0 g/dL. Chapter 5 Diseases of Urinary system