Ammonia neurotoxicity hypothesis 浙医一院 Mechanisms of ammonia neurotoxicity >血氨生成过多:外源性和内生性 >血氨清除过少 Clearance Produce
Ammonia neurotoxicity hypothesis Mechanisms of ammonia neurotoxicity: Produce Clearance ➢血氨生成过多：外源性和内生性 ➢血氨清除过少
Ammonia neurotoxicity hypothesis 浙医一院 Mechanisms of ammonia neurotoxicity Neurotoxic effects of ammonia 4 Alter the transit of amino acids, water, and electrolytes across the neuronal membrane g Inhibit the generation of both excitatory and inhibitory postsynaptic potentials. >氨对脑组织的毒性作用: 令抑制丙酮酸脱氢酶→乙酰辅酶A减少→影响三羧酸循环; 令氨的清除需要浵耗α-酮戊二酸、ATP等物质→影响能量代谢; 令直接作用于神经膜→突触后抑制
Ammonia neurotoxicity hypothesis Mechanisms of ammonia neurotoxicity: ➢ Neurotoxic effects of ammonia: ❖ Alter the transit of amino acids, water, and electrolytes across the neuronal membrane. ❖ Inhibit the generation of both excitatory and inhibitory postsynaptic potentials. ➢ 氨对脑组织的毒性作用: ❖ 抑制丙酮酸脱氢酶→乙酰辅酶A减少→ 影响三羧酸循环； ❖ 氨的清除需要消耗α-酮戊二酸、ATP等物质→影响能量代谢； ❖ 直接作用于神经膜→ 突触后抑制
浙医一院 Ammonia neurotoxicity hypothesis Factors of influence ammonia neurotoxicity: > Excessive dietary protein(饮食中蛋白过量) hypoxia& Dehydration(缺氧或脱水) GI hemorrhage(消化道出血) > Constipation(便秘) Infection(感染) > Hypoglycemia(低血糖)
Ammonia neurotoxicity hypothesis Factors of influence ammonia neurotoxicity: ➢ Excessive dietary protein（饮食中蛋白过量） ➢ Hypoxia & Dehydration（缺氧或脱水） ➢ GI hemorrhage（消化道出血） ➢ Constipation（便秘） ➢ Infection（感染） ➢ Hypoglycemia（低血糖） ➢ ……
浙图一院 False neurotransmitter hypothesis 表2.两大类神经递质 兴奋性神经递质 抑制性神经递质 去甲肾上腺素 頠胺 乙酰胆碱 苯乙醇胺 门冬氨酸 y-氨基丁酸 多巴胺 谷氨酸
False neurotransmitter hypothesis 兴奋性神经递质 抑制性神经递质 去甲肾上腺素 鱆胺 乙酰胆碱 苯乙醇胺 门冬氨酸 多巴胺 γ-氨基丁酸 …… 谷氨酸 表2. 两大类神经递质