Urinary concentration and dilution Concentrative urine浓缩尿: Osmolality of urine> plasma osmolality (300mOsm/LH2O) Di| uted urine稀释尿: Osmolality of urine plasma osmolality
Urinary concentration and dilution Concentrative urine浓缩尿: Osmolality of urine > plasma osmolality (300mOsm/L H2O) Diluted urine稀释尿: Osmolality of urine < plasma osmolality
Formation of Diluted Urine Isosmotic reabsorption of water at proximal tubule Impermeable of water at thick ascending limb LADH> Reabsorption of water at distal tubule and collecting duct>Diluted urine
Formation of Diluted Urine • Isosmotic reabsorption of water at proximal tubule • Impermeable of water at thick ascending limb • ADH→ Reabsorption of water at distal tubule and collecting duct → Diluted urine
Formation of concentrative Urine 个ADH→↑ Reabsorption of water at dist tubule and collecting duct>Concentrative Urine ADH--key element of urinary concentration and dilution What is the drive force of water reabsorption at distal tubule and collecting duct
Formation of Concentrative Urine • ADH→ Reabsorption of water at distal tubule and collecting duct → Concentrative Urine • ADH---key element of urinary concentration and dilution What is the drive force of water reabsorption at distal tubule and collecting duct ?
The osmotic Gradient of the rena medulla THE MEDULLARY OSMOTIC GRADIENT: REVIEW Cortical collecting duct CORTEX PCT DCT Cortex 300 300 Medulla 40 400 1200 OF H MEDULLA onal section the kidney Medullary collecting duct
The Osmotic Gradient of the Renal Medulla
Formation of osmotic Gradient of the renal medulla N Interstitial fluid osmolality ephron (mOsm/kg H,O) Permeability of the 300 Tubular HzO NaCl 300 System NaCI H2O medulla H,O 600 H,O NaCH NaCl HO medulla 1200 NaCl HO H. red
Formation of Osmotic Gradient of the Renal Medulla Permeability of the Tubular System