F ever Jianzhong sheng md, phd Department of Pathology pathophysiology School of Medicine, Zhejiang University Email: shengjzazju.edu.cn
Fever Jianzhong Sheng MD, PhD Department of Pathology & Pathophysiology School of Medicine, Zhejiang University Email: shengjz@zju.edu.cn
Body temperature Normal body temperature 37C( set point,体温调定点) Circadian variation <1oC: 363-3720C e Definition of fever An elevation of core body temperature above the normal range rectal T0.5>olT0.5> axillary T(腋温)
Body temperature •Normal body temperature: 37oC (set point，体温调定点) Circadian variation <1o C ：36.3 - 37.2oC •Definition of fever: An elevation of core body temperature above the normal range rectal T 0.5oC > oral T 0. 5oC > axillary T（腋温）
F ever Pyrogens (exogenous or endogenous) Elevated set-point Maintaining an abnormally elevated Temperature BMR(basal metabolic rate) increases BMR个10% T个0.6°C T个= Elevated set-point
Fever Pyrogens (exogenous or endogenous) Elevated set-point Maintaining an abnormally elevated Temperature BMR (basal metabolic rate) increases T = Elevated set-point BMR 10% = T 0.6oC
Hyperthermia(过热) e fever due to a disturbance of thermal regulatory control excessive heat production (e.g. vigorous exercise, a reaction to some anesthetics decreased dissipation (e.g. dehydration loss of regulation (injury in the hypothalamic regulatory center)
Hyperthermia (过热） •Fever due to a disturbance of thermal regulatory control excessive heat production (e.g. vigorous exercise, a reaction to some anesthetics) decreased dissipation (e.g. dehydration) loss of regulation (injury in the hypothalamic regulatory center)
Hyperthermia Excessive heat Decreased Loss of production dissipation regulation T>unchanged set-point
Hyperthermia Excessive heat production T > unchanged set-point Decreased dissipation Loss of regulation