上浒文通大学 Shanghai Jiao Tong University Therapeutic history Before 1930's:rest,nutrition,fresh air.cure rate 25% @1930~1950's: nutrition therapy physical therapy(artificial pneumothorax,气胸)，cure rate 40% Drugs difficult in entering the cells 1950's:streptomycin,isoniazid,rifampicin; cure rate >90% 21st century:multidrug resistance,TB incidence t
Shanghai Jiao Tong University Therapeutic history Before 1930’s：rest, nutrition, fresh air. cure rate 25% 1930～1950’s： nutrition therapy + physical therapy (artificial pneumothorax,气胸) , cure rate 40% Drugs difficult in entering the cells 1950’s：streptomycin, isoniazid, rifampicin； cure rate >90% 21st century：multidrug resistance, TB incidence ↑
上浒充通大睾 _The evolution of antitubercular agents Shanghai Jiao Tong University The Nobel Prize in Physiology or Medicine 1952 The discovery of the antitubercular activity "for his discovery of streptomycin,the first antibiotic effective against tuberculosis" of aminoglycoside antibiotics streptomycin by Waksman et a/in 1944 ushered in the modern era of tuberculosis treatment. Selman Abraham Waksman
Shanghai Jiao Tong University The discovery of the antitubercular activity of aminoglycoside antibiotics streptomycin by Waksman et al in 1944 ushered in the modern era of tuberculosis treatment. The evolution of antitubercular agents
上游充通大学 Shanghai Jiao Tong University 1952,p-amino-salicylic acid (PAS) 1952，isoniazid 1959,rifampicin 1961,Ethambutol
Shanghai Jiao Tong University 1952, p-amino-salicylic acid (PAS) 1952, isoniazid 1959, rifampicin 1961, Ethambutol …
30 上游文 Shangh 人/10万 2阳 结核 脑血管疾病 01 铂 癌 1QU 心血管疾病 50 0 10 11D 1920 1033 识HO 10F1 1g00 1970 1P80 年 本世纪三大流因及结核的死亡率变化
Shanghai Jiao Tong University
上浒充通大睾 Anti-TB drugs Shanghai Jiao Tong University First-line drugs: Isoniazid(异烟肼) Rifampicin(利福平) Ethambutol(乙胺丁醇) Pyrazinamide(吡嗪酰胺) Streptomycin(链霉素) Second-line drugs: Ethionamide（乙硫异烟胺) Para-aminosalicylic acid(对氨水杨酸) rifapentine(利福喷丁) sparfloxaxcin(司帕沙星)
Shanghai Jiao Tong University Anti-TB drugs First-line drugs: Isoniazid（异烟肼） Rifampicin（利福平） Ethambutol（乙胺丁醇） Pyrazinamide（吡嗪酰胺） Streptomycin（链霉素） Second-line drugs: Ethionamide（乙硫异烟胺） Para-aminosalicylic acid（对氨水杨酸） rifapentine（利福喷丁） sparfloxaxcin（司帕沙星）