Preformulation studies Before the formulation of a drug substance into a dosage form, it is essential that it will be chemically and physically characterized 1) Physical description The majority of drug substances in use today occur as solid materials. Most of them are pure chemical compounds of either crystalline or amorphous constitution
Preformulation studies Before the formulation of a drug substance into a dosage form, it is essential that it will be chemically and physically characterized. 1) Physical description The majority of drug substances in use today occur as solid materials. Most of them are pure chemical compounds of either crystalline or amorphous constitution
a crystal or crystalline solid is a solid material whose constituent atoms, molecules, or ions are arranged in an orderly repeating pattern extending in all three spatial dimensions. An amorphous solid is a solid in which there is no long-range order of the positions of the atoms
◼ A crystal or crystalline solid is a solid material whose constituent atoms, molecules, or ions are arranged in an orderly repeating pattern extending in all three spatial dimensions. ◼ An amorphous solid is a solid in which there is no long-range order of the positions of the atoms
The purity of the chemical substance is essential for its identification as well as for the evaluation of its chemical, physical, and biologic properties Structure, Chemical properties form and reactivity Physical description Particle size Physical properties Crystalline structure Melting point, Solubility
◼ The purity of the chemical substance is essential for its identification as well as for the evaluation of its chemical, physical, and biologic properties. Chemical properties Structure, form and reactivity Physical properties Physical description, Particle size, Crystalline structure, Melting point, Solubility
ability to get to a site Biologic properties of action, Elicit a biologic response
Biologic properties Ability to get to a site of action, Elicit a biologic response
Drugs can be used therapeutically as solids, liquids and gases. Liquids drugs are used to a much lesser extent than solid drugs; gases, even less frequently
Drugs can be used therapeutically as solids, liquids and gases. Liquids drugs are used to a much lesser extent than solid drugs; gases, even less frequently