Target Cell Effect Activation Proliferation Differentiation PLEIOTROPY B cell →LL-4 Proliferation Activated TH cells Thymocyte Proliferation pleiotropiSM Mast cell redundancy REDUNDANCY Proliferation synergy Activated TH cells B cell antagonism SYNERGY IL-4 Induces class switch to igE IL-5 Activated TH cell B cell ANTAGONISM e →L4 Blocks class switch to lgE induced by Il Activated TH cells IFN-Y B cell
◼pleiotropism ◼redundancy ◼synergy ◼antagonism
Cytokines ● General Properties o Functional Categories of cytokines ● Cytokine receptors Biologic Actions
Cytokines ⚫ General Properties ⚫ Functional Categories of Cytokines ⚫ Cytokine Receptors ⚫ Biologic Actions
Functional Categories of Cytokines o Mediators and regulators of innate immunity Tumor necrosis factor (TNF),IL-1,IL-6,IL-12, Type I IFNs, IL-15 IL-18 chemokines O Mediators and regulators of adptive immunity lL-2,4,5,FNg,TGF-β,LT(TNF-β),1-13,etc o Stimulators of hematopoiesis granulocyte-CSF, G-CSF macrophage -CSF, M-CSF granulocyte-macrophage-CSF, GM-CSF) erythropoietin, EPO TPO stem cell factor SCF
Functional Categories of Cytokines ⚫ Mediators and regulators of innate immunity Tumor necrosis factor (TNF), IL-1, IL-6, IL-12, Type I IFNs, IL-15, IL-18,chemokines ⚫ Mediators and regulators of adptive immunity IL-2, IL-4, IL-5, IFN-g, TGF-, LT(TNF- ), IL-13,etc ⚫ Stimulators of hematopoiesis granulocyte-CSF, G-CSF macrophage-CSF，M－CSF granulocyte-macrophage-CSF, GM-CSF) erythropoietin, EPO TPO stem cell factor, SCF
Cytokines ● General Properties o Functional Categories of Cytokines ● Cytokine Receptors Biologic Actions
Cytokines ⚫ General Properties ⚫ Functional Categories of Cytokines ⚫ Cytokine Receptors ⚫ Biologic Actions
Cytokine Receptors o Type l cytokine receptors o Type ll cytokine receptors ● Ig superfamily ● TNF receptors o Seven -transmembrane a-helical receptors Classification of cytokine receptors based on structural homologies among the extracellular cytokine -binding domain
Cytokine Receptors ⚫ Type I cytokine receptors ⚫ Type II cytokine receptors ⚫ Ig superfamily ⚫ TNF receptors ⚫ Seven-transmembrane -helical receptors *Classification of cytokine receptors based on structural homologies among the extracellular cytokine-binding domain