ClassexamplesMode of actionTricyclicNonselective blockers ofAmitriptylineantidepressantsmonoamine uptakeimipramine(TCAs)FluoxetineSelective blocker of5-HTSpecific serotoninreuptake inhibitorsreuptakeParoxetinesertraline5-HT and NASelective blockers of 5-HTvenlafaxineand NAreuptake inhibitorsPhenelzineMonoamineoxidaseNon-competitive,noninhibitor(MAO)selective,irreversibletranylcypromineblockers Of MAOAtypicalMianserinAct by various mechanismstrazodonethat are poorly understood
Class examples Mode of action Tricyclic antidepressants (TCAs) Amitriptyline imipramine Nonselective blockers of monoamine uptake Specific serotonin reuptake inhibitors Fluoxetine Paroxetine sertraline Selective blocker of 5-HT reuptake 5-HT and NA reuptake inhibitors venlafaxine Selective blockers of 5-HT and NA Monoamine oxidase inhibitor(MAO) Phenelzine tranylcypromine Non-competitive, nonselective, irreversible blockers Of MAO Atypical Mianserin trazodone Act by various mechanisms that are poorly understood
TricyclicAntidepressants-AmitriptylineandimipraminePharmacologic effects and mechanismofaction1. CNS:To normal human being, imipramine induces fatigue,drowsiness, and the person cannot concentrate his mind.For depression patients, the tricyclic compounds elevatemood, increase alertness and improve appetite, sleep.The appearance of antidepressant effects typicallyrequires administration of the drug for several weeks
Tricyclic Antidepressants -Amitriptyline and imipramine Pharmacologic effects and mechanism of action 1. CNS: To normal human being, imipramine induces fatigue, drowsiness, and the person cannot concentrate his mind. For depression patients, the tricyclic compounds elevate mood, increase alertness and improve appetite, sleep. The appearance of antidepressant effects typically requires administration of the drug for several weeks
Mechanism:Tricyclics block the amine (norepinephrine andserotonin) reuptake pumps and potentiate thec amines.Suchan actionactionsofbiogenicofpermitssalongersojournpresumablyneurotransmitter at the receptor site
Mechanism: Tricyclics block the amine (norepinephrine and serotonin) reuptake pumps and potentiate the actions of biogenic amines. Such an action presumably permits a longer sojourn of neurotransmitter at the receptor site