第5章立体化学 Stereochemistry
2 第5章 立 体 化 学 Stereochemistry
enzyme Me Me2N P Et darvon Darvon is a painkiller. Its enantiomer is an anticough agent
3
Biological Significance of Chirality Enantiomers of Epinephrine H3C⊕ Enzyme Anionic Flat area Anionic Flat area site site Not Occupied Occupied (+)-Epinephrine (-)-Epinephrine Poorer Fit D Less Active Better Fit More Active
4 ◆Biological Significance of Chirality
手性药物 的工 COOH 米 Ibuprofen (Advil) 日异丁苯丙酸，布洛芬（抗炎、镇痛药） 反应停 5
5 N N O O O O H H COOH H 手性药物 Ibuprofen (Advil) 异丁苯丙酸,布洛芬(抗炎、镇痛药) 反应停 * *
侣里 beneficial sedative 米 and anti-nausea drug Caused serious birth 米 defects when taken by pregnant women!
6 N N O O O O H H N N O O O O H H * beneficial sedative and anti-nausea drug * Caused serious birth defects when taken by pregnant women!