固有免疫应答 Integument Mucosa Chemicals Body surfaces Stomach Subcutaneous HCL 6 FIsS Acid pl
一、固有免疫应答
巨细胞、NK细胞—非特异性杀伤 细胞因子( Cytokines)—导致炎症细 胞渗出——引起炎症
• 巨噬细胞、NK细胞——非特异性杀伤 • 细胞因子（Cytokines）——导致炎症细 胞渗出——引起炎症
、适应性免疫应答 ③丁B淋巴细胞被抗原活化抗原是指一组能 被或B细胞识别的有机物质,包括多肽、 寡糖及脂质酸等小分子。T、B细胞通过 CR、BCR的识别有严格的特异性。 T、B细胞的克隆扩增及分化B细胞通过 BCR识别和结合抗原而活化,在B细胞生长 因子作用下,进行克隆扩增。TCR需与 APC处理过的抗原多肽结合,在T细胞生长 因子作用下进行克隆扩增
二、适应性免疫应答 • T、B淋巴细胞被抗原活化 抗原是指一组能 被T或B细胞识别的有机物质，包括多肽、 寡糖及脂质酸等小分子。T、B细胞通过 TCR、BCR的识别有严格的特异性。 • T、B细胞的克隆扩增及分化 B细胞通过 BCR识别和结合抗原而活化，在B细胞生长 因子作用下，进行克隆扩增。TCR需与 APC处理过的抗原多肽结合，在T细胞生长 因子作用下进行克隆扩增
haracteristics of Adaptive Immunity- Immune response is highly specific for the antigen that triggered it Receptors on surface of immune cells have same specificity as the antibody/effector activity that will be generated Exposure to antigen creates an immunologic memory. Due to clonal expansion and creation of a large pool of cells committed to that antigen Subsequent exposure to the same antigen results in a rapid and vigorous response
Characteristics of Adaptive Immunity • Immune response is highly specific for the antigen that triggered it. – Receptors on surface of immune cells have same specificity as the antibody/effector activity that will be generated • Exposure to antigen creates an immunologic “memory.” – Due to clonal expansion and creation of a large pool of cells committed to that antigen – Subsequent exposure to the same antigen results in a rapid and vigorous response