宿主体内的免疫系统谀别和清除 统三大物的生和病现 功能生理性反应(有利)病理性反应(有害) 免疫防御清除病原微生畅 及其他抗原 超敏反应(过度) 免疫缺陷病(不足) 免疫自稳请除损伤或衰老 自身免疫病 的细胞,免疲网 絡调节免疫应答 免疫监视清除突吏或哈变 肿癖发生 的恶性细胞 持续病毒感染
宿主体内的免疫系统识别和清除
免疫系统是由免疫组织和器官、免疫细胞及 免疫活性分子等组成。 免疫细胞对病原体或肿瘤细胞的适当应答, 使之清除。 免疫应答过高或过低,均为异常
• 免疫系统是由免疫组织和器官、免疫细胞及 免疫活性分子等组成。 • 免疫细胞对病原体或肿瘤细胞的适当应答, 使之清除。 • 免疫应答过高或过低,均为异常
第二节免疫应答的类型及作用 固有免疫应答( innate immune response)皮肤黏膜、局部分泌物质、吞 噬细胞、NK细胞和补体 适应性免疫应答( adaptive immune response)T、B细胞
第二节 免疫应答的类型及作用 • 固有免疫应答(inanate immune response)皮肤黏膜、局部分泌物质、吞 噬细胞、NK细胞和补体 • 适应性免疫应答(adaptive immune response) T、B细胞
Two types of immunity- Innate immunity(not antigen-specific) Anatomical barriers Mechanical Biochemical Non-specific(eg. Low pH in stomach) o Receptor-driven(eg. PAMP-recognition) Adaptive immunity(antigen-specific) Receptor-drⅳven Pre-existing clones programmed to make a speciTIc immune response (humoral/cellular)
Two types of immunity • Innate immunity (not antigen-specific) – Anatomical barriers – Mechanical – Biochemical • Non-specific (eg. Low pH in stomach) • Receptor-driven (eg. PAMP-recognition) • Adaptive immunity (antigen-specific) – Receptor-driven – Pre-existing clones programmed to make a specific immune response (humoral/cellular)
The products of the immune response may be used To diagnose disease O To monitor disease progress As reagents in assays to detect and quantify other substances
The products of the immune response may be used • To diagnose disease • To monitor disease progress • As reagents in assays to detect and quantify other substances