Immunodeficiency diseases Wang Xiaochuan Department of Clinical Immunology. Childrens Hospital of Fudan University Wang Xiaochuan Children's Hospital
Wang Xiaochuan Children’s Hospital Immunodeficiency diseases Wang, Xiaochuan Department of Clinical Immunology, Children’s Hospital of Fudan University
Immunologic disorders Pathogens nections Immunity immunity Tinan PID Autoimmune disease Allergy Tumor Immunity Environment Material Wang Xiaochuan Children's Hospital
Wang Xiaochuan Children’s Hospital Pathogens Environment Material Immunity Infectious Immunity Allergy Tumor Immunity Autoimmune Disease PID
Immunocompromised Host Individual who has one or more defects in the body's natural defense mechanisms which are sufficiently severe to predispose the host to life threatening infection Primary -PID, damage to anatomical barriers Secondary -infection, tumor, drug, others Physiology- Infants, aged Wang Xiaochuan Children's Hospital
Wang Xiaochuan Children’s Hospital Immunocompromised Host • Individual who has one or more defects in the body’s natural defense mechanisms which are sufficiently severe to predispose the host to lifethreatening infection • Primary - PID, damage to anatomical barriers • Secondary - infection, tumor, drug, others • Physiology- Infants, aged
Characteristics of Immunoglobulines Igg lgm iga led lgE Serum con.(mg/d)120012020030.01 Percentage 70-805-1010-15<1<0.01 Half life( days) 21 72.82.3 Distribution (9o) 45 80 457550 Quantity(mg/kg)1150492301.50.04 Synthesis(mg/kg/D) 35 7 25 0.4 0.02 Transport through placenta Wang Xiaochuan Children's Hospital
Wang Xiaochuan Children’s Hospital Characteristics of Immunoglobulines IgG IgM IgA IgD IgE Serum Con. (mg/dl) 1200 120 200 3 0.01 Percentage 70-80 5-10 10-15 <1 <0.01 Half life(days) 21 5 7 2.8 2.3 Distribution (%) 45 80 45 75 50 Quantity (mg/kg) 1150 49 230 1.5 0.04 Synthesis(mg/kg/D) 35 7 25 0.4 0.02 Transport through placenta + - - - -
Development of Immunoglobulin Igg level of Infant 100% Igg from mother igg of infant birth Wang Xiaochuan Children's Hospital
Wang Xiaochuan Children’s Hospital Development of Immunoglobulin IgG from motherIgG of infant birth 6M 100% IgG level of Infant