1901 Motor systems The basal ganglia and Drugs used for the treatment of parkinson's disease Zhang Bin(张斌) Institute of Pharmacology School of medicine Shandong University
1 Motor systems II: The basal ganglia and Drugs used for the treatment of Parkinson’s disease Zhang Bin（张斌） Institute of Pharmacology School of Medicine Shandong University
Spinal cord Muscle Motor cortex Th alamos Other neuro transmitters GABA Acetylcholine Globus When dopamine-producing Pallidus die. loss of dopamine release in the Pars compacta striatum causes the acetylcholine producers there to overstimulate their target Dopamine neurons, thereby triggering a chain reaction of abnormal Striatum signaling leading to impaired Substantia nigra mobility Parkinson's disease
1. Components of Basal Ganglia VL nucleus of Caudate nucleus neostriatum striatum pallidus(paleostriatum) Subthalamic Substantia nigra
1. Components of Basal Ganglia 3 neostriatum striatum (paleostriatum)
1. Caudate nucleus(尾状核) 2 Putamen(壳核豆状核壳) 新纹状体 3. Globus pallidus(GP)(苍白球,旧纹状体) 4. Substantia Nigra(SN)(黑质 Pars compacta(p.c)(致密部) Pars reticulata(pr)(网状部) 5. Subthalamic nucleus(STN)(丘脑底核) cortex caudate &x putamen globus ext. pallidus thalamus subthalamic nucleus substantia nigra 新纹状体是基底节的核心,许多神经传入进来,也会 发出神经纤维到其他部位,构成回路调控躯体运动
• 1. Caudate Nucleus (尾状核） • 2. Putamen (壳核,豆状核壳） • 3.Globus Pallidus (GP) （苍白球，旧纹状体） • 4. Substantia Nigra (SN)（黑质） Pars Compacta (p.c.) (致密部） Pars Reticulata (p.r.) （网状部） • 5. Subthalamic Nucleus (STN) (丘脑底核） 4 新纹状体 新纹状体是基底节的核心，许多神经传入进来，也会 发出神经纤维到其他部位，构成回路调控躯体运动
2. Medium spiny neuron in striatum (MSN中型多棘神经元) D) MSN is the main efferent neurons in neostriatum 2)MSN( Dendrites)接受的 afferent神经: Glu neurons in cortex c)multipolar axon soma DA neurons in snc endnotes Ach neurons in striatum GABA neurons in striatum 3)MSN axons compose efferent system, with GABa as the neurotransmitter
2. Medium spiny neuron in striatum (MSN,中型多棘神经元) 1) MSN is the main efferent neurons in neostriatum 2) MSN（ Dendrites）接受的afferent神经: Glu neurons in cortex DA neurons in SNc Ach neurons in striatum GABA neurons in striatum 3) MSN axons compose efferent system, with GABA as the neurotransmitter 5