pharmacokinetics Department of pharmacology Yang Fang-ju(杨芳矩) 2010.3
pharmacokinetics Department of pharmacology Yang Fang-ju (杨芳矩) 2010.3
Section 1 drug process in the body o 1. classification of drug process in the body It includes absorption, distribution, metabolism. excretion o Metabolism and excretion are called elimination
Section 1 drug process in the body ⚫ 1. classification of drug process in the body ⚫ It includes absorption, distribution, metabolism, excretion. ⚫ Metabolism and excretion are called elimination
tissue. cells bind dissociation Blood plasma absorption Dissociated drug excretion B ound arug metabolite biotransformation Process of drugs in the body
Dissociated drug tissue, cells bind dissociation excretion Bound drug metabolite biotransformation Blood plasma absorption Process of drugs in the body
o 2. transportation of drugs across membranes o The absorption, distribution, biotransformation and excretion of a drug all involve its passage across cell membranes Transported model: ●(1) Passive diffusion o It transports along a concentration gradient ●※ It needs not metabolic energy ●※ it is usually determined by its pka, lipid- water partition coefficient, molecular weigh, and ph gradient in solution
⚫ 2. transportation of drugs across membranes ⚫ The absorption, distribution, biotransformation, and excretion of a drug all involve its passage across cell membranes. ⚫ Transported model: ⚫ ⑴Passive diffusion ⚫ It transports along a concentration gradient ⚫ ※ It needs not metabolic energy ⚫ ※ it is usually determined by its pKa, lipidwater partition coefficient, molecular weigh, and pH gradient in solution