Pharmacokinetics of drugs in fetus Absorption(fetus) Blood skin circulation placental swallow barrier Gastrointestinal Serum of mother amniotic fluid tract Re-absorption Blood ->Drug discharged into amniotic fluid circulation with fetal urine 11
Absorption(fetus) placental Gastrointestinal swallow skin Blood circulation Pharmacokinetics of drugs in fetus barrier 11 amniotic fluid Gastrointestinal tract swallow Drug discharged into amniotic fluid with fetal urine Blood circulation serum Serum of mother Re-absorption
Pharmacokinetics of drugs in fetus Distribution(fetus) >Less distribution of fat soluble drugs:Less fat >Easy to enter tissue: Less plasma protein,more free drugs in serum >More drug distribution in some organs More Blood flow to Liver,brain,and heart. >Easy enter central nervous system:Poor blood brain barrier 12
Distribution(fetus) Less distribution of fat soluble drugs: Less fat Easy to enter tissue: Pharmacokinetics of drugs in fetus Less plasma protein ,more free drugs in serum More drug distribution in some organs More Blood flow to Liver, brain, and heart. Easy enter central nervous system: Poor blood brain barrier 12
Pharmacokinetics of drugs in fetus Metablism (fetus) High drug concentration in fetus (For most drugs) Lower activity of liver metabolite enzyme e.g.Poor metabolism of Asprin in fetus. Translate to harmful metabolism(For some drugs) e.g.phenytoin itself can not induce teratogenesis,but the Metabolism of phenytoin can result in teratogenesis. 14
Metablism (fetus) e.g. Poor metabolism of Asprin in fetus. Lower activity of liver metabolite enzyme High drug concentration in fetus (For most drugs) Pharmacokinetics of drugs in fetus e.g. Poor metabolism of Asprin in fetus. Translate to harmful metabolism(For some drugs) e.g. phenytoin itself can not induce teratogenesis, but the Metabolism of phenytoin can result in teratogenesis. 14