Pharmacokinetics of drugs Pharmacokinetics of drugs in mother Pharmacokinetics of drugs in fetus 5
Pharmacokinetics of drugs Pharmacokinetics of drugs in mother Pharmacokinetics of drugs in fetus 5
Pharmacokinetics of drugs in mother Absorption Gastric acid ● Changes of Gastric Hormone emptying time Absorption of Oral drugs Peristalsis Vomit in early pregnant Absorption of poor circulation of lower limbs injection drugs 6
Pharmacokinetics of drugs in mother Absorption Gastric acid Changes of Gastric Hormone Absorption of Oral drugs Gastric emptying time Peristalsis Hormone Vomit in early pregnant 6 poor circulation of lower limbs Absorption of injection drugs
Pharmacokinetics of drugs in mother Distribution >Increase of blood volume Drug concentration >Distribution of drugs to fetal in serum Plasma free Drug concentration protein ↓ in tissue 个 >Fatty tissue↑I Fat soluble drugs distribution 个 7
Distribution Increase of blood volume Distribution of drugs to fetal Drug concentration in serum Pharmacokinetics of drugs in mother 7 Plasma free protein drugs Drug concentration in tissue Fatty tissue Fat soluble drugs distribution
Pharmacokinetics of drugs in mother Metablism Hepatic microsomal enzyme activity Metablism speed 9
Metablism Hepatic microsomal enzyme activity Pharmacokinetics of drugs in mother Metablism speed 9
Pharmacokinetics of drugs in mother Excretion Blood flow in kidney elimination Glomerular filtration in kidney rate (50%) Later period: Elimination Blood flow in kidney↓ in kidney 10
elimination Excretion Blood flow in kidney Pharmacokinetics of drugs in mother Glomerular filtration in kidney rate （50%） Blood flow in kidney 10 Elimination in kidney Later period：