Section IFundaments of MicrobiologyMicrobial MetabolismSHIHEZI UNIVERSITY
Section I Fundaments of Microbiology Microbial Metabolism SHIHEZI UNIVERSITY
KEY TERMSFocal metaboliteGlucosePyruvateFermentationRespirationTricarboxylic acid (TCA) cycle or Krebs cycleOxidative phosphorylationGlyoxylate pathwaySHIHEZI UNIVERSITY
KEY TERMS Focal metabolite Glucose Pyruvate Fermentation Respiration Tricarboxylic acid (TCA) cycle or Krebs cycle Oxidative phosphorylation Glyoxylate pathway SHIHEZI UNIVERSITY
ROLE OF METABOLISMINBIOSYNTHESIS & GROWTHMicrobial growth requires the polymerization ofbiochemical building blocks into proteinsnucleic acids, polysaccharides, and lipids The building blocks must come preformed in thegrowth medium or must be synthesized by thegrowing cellsBiosynthetic polymerization reactions demand thetransfer of anhydride bonds from ATPSHIHEZI UNIVERSITY
ROLE OF METABOLISM IN BIOSYNTHESIS & GROWTH Microbial growth requires the polymerization of biochemical building blocks into proteins, nucleic acids, polysaccharides, and lipids The building blocks must come preformed in the growth medium or must be synthesized by the growing cells Biosynthetic polymerization reactions demand the transfer of anhydride bonds from ATP SHIHEZI UNIVERSITY
Focal Metabolite: The few precursors for the biosyntheticorigins of building blocks and coenzymesFocal metaboliteIntermediatesEnd productsPolysaccharidesHexose phosphatesNucleic acidsHistidinePentosephosphatesTryptophanGlucose 6-phosphate→PhenyalanineTetrosephosphate→ChorismateTyrosine+ LipidsTriose phosphatesGlycine3-Phosphoglycerate→Serine→ CysteineTryptophanFigure61Biosyntheticendproductsfomedfomglucos6-phosphateCarbohydratephophateestersofvaryingchainlengthserveasintermediatesinthebiosyntheticpathwaysSHIHEZIUNIVERSITY
Focal Metabolite: The few precursors for the biosynthetic origins of building blocks and coenzymes SHIHEZI UNIVERSITY
Four Categories of MicrobialMetabolismPathways for the interconversion of focametabolitesAssimilatory pathways for the formationof focal metabolitesBiosynthetic sequences for the conversionof focal metabolites to end productsPathways that yield metabolic energySHIHEZI UNIVERSITY
Four Categories of Microbial Metabolism 1. Pathways for the interconversion of focal metabolites 2. Assimilatory pathways for the formation of focal metabolites 3. Biosynthetic sequences for the conversion of focal metabolites to end products 4. Pathways that yield metabolic energy SHIHEZI UNIVERSITY