Section III BacteriologyPathogenesis of Bacterial InfectionSHIHEZI UNIVERSITY
Section III Bacteriology Pathogenesis of Bacterial Infection SHIHEZI UNIVERSITY
KEY TERMS PathogenExtra/intracellular pathogenCompromised hostOpportunistic infection InfectionExotoxinEndotoxin Infectious diseases Koch's postulatesAutoimmunity TransmissionBioterrorismAdhesion PenetrationInvasiveness/spreadSHIHEZI UNIVERSITY
KEY TERMS Pathogen Opportunistic infection Infection Infectious diseases Koch’s postulates Transmission Adhesion Penetration Invasiveness/spread Extra/intracellular pathogen Compromised host Exotoxin Endotoxin Autoimmunity Bioterrorism SHIHEZI UNIVERSITY
GLOSSARYAeasonaachmnhossInvaoThposswheyacteriaanmaparasitewhichbacteriasticktothesurfacesofhostcells.Oncefugindirustispin the bodybacriahntthymNonpathogenAmicroorganismthatdoesnotcausedisinitialstepintheinfectionprocess.Thetermsadherease:maybepartofthenormalfloraenceadsonandatachmntarftenusedintchangeably.OpportunisticpathogenAnagentcapableofcausinCarrierAeronoranmalwithasymptomaticinfectiodiseaseonlywhenthehost'sresistanceisimpaired(iewhenthepatientis"mmunocompromised")thatcanbetransmittedtoanothersusceptiblepersonPathgenmicoorganmapablecaungdiseasor animal.InfectionMultiplicatiofaninfectiousagentwithinthePathogenicityTheabilityofaninfectiousagenttocausepody.Multiplicationfthebacteriathatarepartfthdisease seealso virulenceToxigenicityTheabilityfamicroorganismproduceamahtrsakerallynotconsideredaninfectionontheotherhandtoxinthatcontributestothedevelopmentofdiseaseViruunttiltaumultplicatioanbriaamaspecies)evenifthepersonisasymptomaticsdisease.Virulentagentscausedisease when introduceddeemed an infection.intothehostinsmallnumbers.Virulenceinvolvesinvasionand toxigenicity (see above)SHIHEZI UNIVERSITY
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Pathogen Definition: a microorganism capable ofcausing diseaseCharacteristicsTransmissibility Adherence to host cellsInvasion of host cells and tissuesToxigenicityAbility to evade the host's immune systemSHIHEZI UNIVERSITY
Pathogen Definition: a microorganism capable of causing disease Characteristics Transmissibility Adherence to host cells Invasion of host cells and tissues Toxigenicity Ability to evade the host’s immune system SHIHEZI UNIVERSITY
Identifying Bacteria That CauseDisease:Koch's postulates Isolateddiseased not healthy peoplePostulale 1The sutpectad penogirnipaninshauldtencasdlftetoard ataerthon ecthnGrowthmnddbiod on pure culture39Postulate2hesusoecdona8gmetashoaid be ponimpreueolthyanindsuspec Induce diseasepithognosalehealhatBsuspendpatogerPostulate3Calb tomapuectechtesedogait susceptible animalsshold caisedehaty armeoetentbymosep Re-isolatedPestulate 4The opaniomshoud bedudstonibeteseasteF susceptible animalsPurealnesoidsfpatrognasbesameogerisnas beteSHIHEZI UNIVERSITY
Identifying Bacteria That Cause Disease: Koch's postulates Isolated diseased not healthy people Growth pure culture Induce disease susceptible animals Re-isolated susceptible animals SHIHEZI UNIVERSITY