HUASHAN HOSPITA 莘山院 MECHANISMS OF ESSENTIAL HYPERTENSION 3) >Insulin Resistance/ hyperinsulinemia increase arterial pressure. mechanism unclear o Hyperinsulinemia produces renal sodium retention and increases sympathetic activity o Vasular smooth-muscle hypertrophy secondary to the mitogenic action of insulin O Insulin modifies ion transport across the cell membrance
Insulin Resistance/ hyperinsulinemia— increase arterial pressure…mechanism unclear Hyperinsulinemia produces renal sodium retention and increases sympathetic activity Vasular smooth-muscle hypertrophy secondary to the mitogenic action of insulin Insulin modifies ion transport across the cell membrance. MECHANISMS OF ESSENTIAL HYPERTENSION (3)
HUASHAN HOSPITA 莘山院 MECHANISMS OF ESSENTIAL HYPERTENSION (4) Sympathetic nervous hyperactivity Endothelial cell dysfunction >Deficiencies of various vasodepressor hormones
Sympathetic nervous hyperactivity Endothelial cell dysfunction Deficiencies of various vasodepressor hormones MECHANISMS OF ESSENTIAL HYPERTENSION (4)
HUASHAN HOSPITA 莘山院 PATHOLOGY
PATHOLOGY
HUASHAN HOSPITA 莘山院 Heart--The hypertension creates a greater pressure load on the heart to induce the hypertrophy. This left ventricle is very thickened(slightly over 2 cm in thickness), but the rest of the heart is not greatly enlarged This is typical for hypertensive heart disease
This left ventricle is very thickened (slightly over 2 cm in thickness), but the rest of the heart is not greatly enlarged. This is typical for hypertensive heart disease. Heart--The hypertension creates a greater pressure load on the heart to induce the hypertrophy
HUASHAN HOSPITA 莘山院 The left ventricle is markedly thickened in this patient with severe hypertension that was untreated for many years. The myocardial fibers have undergone hypertrophy
The left ventricle is markedly thickened in this patient with severe hypertension that was untreated for many years. The myocardial fibers have undergone hypertrophy