Development ofHematopoieticOrgans Fetal hematopoiesisHematopoiesis after birth- Bone marrow hematopoiesisExtrmedullary（骨髓外）hematopoiesisHEMATOLOGY/ONCOLOGY,CHILDREN'SHOSPITAL
D e v e l o p m e n t of Hematopoietic Organs • Fetal hematopoiesis • Hematopoiesis a f t e r birth – Bone marrow hematopoiesis – Ext rmedulla r y（骨髓外） hema t opoie sis HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
Development ofHematopoieticOrgansHematopoiesis after birth-BonemarrowhematopoiesisAllblood cellsare produced inthe marrowafter 2nd trimester.Newborn and early infancy: red marrow. 5-7yr :yellowmarrow-Extramedullary hematopoiesisHEMATOLOGY/ONCOLOGY,CHILDREN SHOSPITAL
D e v e l o p m e n t of Hematopoietic Organs • Hematopoiesis a f t e r birth – Bone marrow hematopoiesis • All blood cells are produced in the marrow after 2nd trimester • Newborn and early infancy: red marrow • 5-7yr : yellow marrow – Extramedullary hematopoiesis HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
Samplese Only-CopyrightedSaThe site for bone marrow aspiration:一tibia（胫骨）Newbornand earlyinfancy-Aftertheinfancyperiod一posteriorsuperioriliacspine（后上脊）
The site for bone marrow aspiration: Newborn and early infancy — tibia(胫骨) After the infancy period — posterior superioriliacspine（髂后上脊）
Development ofHematopoieticOrgansHematopoiesis after birth-Bone marrow hematopoiesis-Extramedullaryhematopoiesis（骨髓外造血）.In disease status: red cell productionhematopoietic tissue.blood production expands to replace fatty marrow.blood cells production extends to extramedullarysites (liver and spleen)HEMATOLOGY/ONCOLOGY,CHILDREN SHOSPITAL
D e v e l o p m e n t of Hematopoietic Organs • Hematopoiesis a ft e r b irth – Bone marrow hematopoiesis – Extramedullary hematopoiesis (骨髓外造血) • In disease s t at us : red cell production hematopoietic tissue . • blood production expands to replace fat t y marrow. • blood cells production extends to extramedullary sites ( liver and spleen). HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
Development ofHematopoieticOrgansHematopoiesis after birth-Extramedullary hematopoiesisQA: In infants and children,hemolyticdiseaseresults ina relativelgreater enlargement of the liver andspleen than in adults?HEMATOLOGY/ONCOLOGYCHILDRENSHOSPITAL
D e v e l o p m e n t of Hematopoietic Organs • Hematopoiesis a ft e r birth –Ext r amedulla r y hema t opoie sis QA: In infants and children, hemolytic disease results in a relatively greater enlargement of the liver and spleen than in adults ? HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L