Development of theHematopoietic Blood CellsPluripotent Stem Cells:-which are capable of both self-renewal andof clonal maturation into all blood celllineages.Progenitorcellsdifferentiate（分化）undertheinfluenceofhematopoieticgrowthfactorsHEMATOLOGYIONCOLOGYCHILDREN·SHOSPITAL
D e v e l o p m e n t of t h e Hematopoietic B l o o d Cells • Pluripotent Stem Cells: –which a r e ca pa ble of bot h s elf- r enewa l a nd of clona l ma t ur a t ion int o a ll blood cell lineages. –Progenitor cells d ifferen tia te ( 分 化 ） under t he influence of hema t opoiet ic gr owt h fa ctors HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
HematopoieticstemcellProgenitorsLymphoidMyeloidErythroidBone marrowBlood/TissuesBasophilBcellNeutrophilTcellRBCMastMegakaryocyteNK cellcellOEosinophieMacrophageDendriticcellPlatelets
Table2.The Development ofBloodCPROGENITORCYTOKINESPRODUCG-CSFCFU-GMNUTROPHIL粒集落刺激因子TPOPLTCFU-Meg血小板生成素CFUEEPORBCBFUE红细胞生成素HEMATOLOGY/ONCOLOG, CHILDREN'SHOSPITAL
Table 2.The Development of BloodCells PROGENITOR CYTOKINES PRODUC G-CSF NUTROPHIL 粒-集落刺激因子 C FU -G M TPO PLT 血小板生成素 CFU-Meg EPO R B C 红细胞生成素 C FU -E B FU -E HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
HEMATOLOGY/ONCOLOGY,CHILDREN'SHOSPITAL
HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
BloodCell CountsDr.Jie Yu,MD.ProfessorThe department of Pediatric,Hematology/Oncology,FMATDLOYAHNGOLOGCHILIRENHHSPITAL
Blood Cell Counts Dr.Jie Yu, MD. Professor The department of Pediatric, Hematology/Oncology, HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L