In the embryo and fetus,constant changes characterizeall phases of hematopoiesisHematopoiesis造血lHematopoietic造血的HEMATOLOGY/ONCOLOG, CHILDREN'SHOSPITAL
I n t h e e m b r yo a n d f e t u s , c o n s t a n t c h a n g e s c h a r a c t e r i z e a ll p h a s e s o f h e m a t o p o i e s i s . Hematopoiesis 造血 Hematopoietic 造血的 HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
Contents& Aims Hematopoietic organ. Hematopoietic blood cellsHematopoiesis造血Hematopoietic造血的HEMATOLOGY/ONCOLOGYCHILDRENSHOSPITAL
C o n t e n t s & Aims • Hematopoietic organ • Hema t opoiet ic blood ce lls Hematopoiesis 造血 Hematopoietic 造血的 HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
Development ofHematopoieticOrgans·Fetal hematopoiesis-Mesoblastic Hematopoiesis（中胚层）(肝脏)-Hepatic Hematopoiesis（骨髓）-Myeloid HematopoiesisHematopoiesis after birthHEMATOLOGY/ONCOLOGY,CHILDREN SHOSPITAL
D e v e l o p m e n t of Hematopoietic Organs • Fetal hematopoiesis –Mesobla st ic Hema t opoiesis （中胚层) – Hepatic Hematopoiesis – Myeloid Hematopoiesis (肝脏） （骨髓） • Hema t opoiesis a ft er birt h HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
·Table l. Fetal HematopoiesisYTSITESTIMEPRODUCYolkMeasoblastic10-14thdayErythroidSac（红系）3-4wk:primitiveblastshematopoisis10-12wk:ceasedHepatic6-8wk:appearLiverErythroid12-16wk:activehematopoiesiSSpleen6mo:diminish/stopatbirthMyeloidBone4mo:startErythroidNeutrophilshematopoiesimarrow6mo:increase/steadyMacrophagesafterbirth:theonlySHEMATOLOGY/ONCOLOGY,CHILDREN'S HOSPITAL
SITES TIME PRODUC Measoblastic hematopoisis Yolk Sac 10-14th day 3-4wk:primitive blasts 10-12wk:ceased Erythroid （红系） Hepatic hematopoiesi s Liver Spleen 6-8wk:appear 12-16wk:active 6mo:diminish/ stop at birth Erythroid Myeloid hematopoiesi s Bone marrow 4mo:start 6mo:increase/steady after birth: the only Erythroid Neutrophils Macrophages Table 1. Fetal H e m a t o p o i e s i s HEMATOLOGY/ONCOLOGY, CHILDREN’S H O S P I T A L
O3?胎儿期造血生后造血100爱肝脏县椎骨福75marrow胸骨50股骨胫骨肋骨252345S678910203040506070胎儿（月）年龄(岁)出生图28-1胎儿期和生后造血Trimester·三个月，学期
Trimester 三个月，学期