Tuberculous Meningitis CHCUMS CHCU DIVISION OF INFECTIOUS DISEASEAND GASTROENTEROLOGY November 24th. 2004
1 Tuberculous Meningitis CHCUMS DIVISION OF INFECTIOUS DISEASE AND GASTROENTEROLOGY November 24th, 2004
EPIDEMIOLOGY-TBM Tuberculous Meningitis (TBM The younger the children, the more 'eadily to develop TBM. o 60%in Children aged 1-3 years ◆ Death rate:15-30%
2 EPIDEMIOLOGY - TBM Tuberculous Meningitis (TBM) ◆ The younger the children, the more readily to develop TBM. ◆ 60% in Children aged 1-3 years ◆ Death rate: 15-30%
TBM (Tuberculous meningitis) TBM is the most serious complication of tuberculosis in children and is usually fatal without treatment o tBM always be a part of systemic disseminated tuberculosis TBM often occurs within 1 vear of initial infection, especially in the first 2 to 6 months of infection
3 TBM (Tuberculous meningitis) ◆ TBM is the most serious complication of tuberculosis in children and is usually fatal without treatment. ◆ TBM always be a part of systemic disseminated tuberculosis. ◆ TBM often occurs within 1 year of initial infection, especially in the first 2 to 6 months of infection
PATHOPHYSIOLOGY Primary Bacteremia Com plex Brain Tuberculous B one Bacilli ☆ Lung Kidne Miliary TB Meningitis)(Subarachnoid Space Trauma/Diseases measles, pertussi Tuberculomas Brain or Spinal Cord Aerenchyma R 4
4 Tuberculous Bacilli Primary Complex Bacteremia Rich Foci Subarachnoid Space Brain or Spinal Cord Perenchyma Tuberculomas Meningitis PATHOPHYSIOLOGY Trauma/Diseases measles, pertussis Miliary TB
PATHOLOGICAL EFFECTS Meninges Diffuse Hyperemia ◆ Edema Inflammatory Exudates Conformation of Tubercles
5 PATHOLOGICAL EFFECTS Meninges ◆ Diffuse Hyperemia ◆ Edema ◆ Inflammatory Exudates ◆ Conformation of Tubercles