血栓和止血检查 (三)血液凝固 凝血系统被激活,血液凝固,纤维 蛋白网络RBC、WBC形成红色血栓。 止血、纤溶、修复血管 Tests of thrombus and haemostasis
2025/5/18 6 血 栓 和 止 血 检 查 Tests o f t hr o m bu s an d h ae m o st a s i s (三)血液凝固 凝血系统被激活,血液凝固,纤维 蛋白网络RBC、WBC形成红色血栓。 止血、纤溶、修复血管
血栓和止血检查 Platelet adhesion Platelet release Dense bodies ◆Release of ADP GPla Injured vessel wall exposing collagen GPlb- Prostaglandin synthesis wF Serotonin TXA2 Platelet aggregation Coagulation Vasoconstriction Fibrinogen Blood flow to injured area reduced ④ 88目808g8鸣 PF-3 Fibrin ADP Tests of thrombus and haemostasis
2025/5/18 7 Tests o f t hr o m bu s an d h ae m o st a s i s 血 栓 和 止 血 检 查
血栓和止血检查 二、凝血机制(mechanism of coagulation) L.凝血因子(coagulation factors) 2.凝血因子止血作用 内擬(intrinsic coagulation pathway) 外擬(extrinsic coagulation pathway) 共同途径(common coagulation pathway) 内、外凝血途径不能截然分开,有交叉。 Tests of thrombus and haemostasis
2025/5/18 8 血 栓 和 止 血 检 查 Tests o f t hr o m bu s an d h ae m o st a s i s 二、凝血机制(mechanism of coagulation) 1. 凝血因子 (coagulation factors) 2. 凝血因子止血作用 内凝 (intrinsic coagulation pathway) 外凝( extrinsic coagulation pathway) 共同途径(common coagulation pathway ) 内、外凝血途径不能截然分开,有交叉
血栓和止血检查 Surface Contact (Intrinsic Pathway) XIla XⅫ Injury Xla X (Extrinsic Pathway) X Ca. u CIXa VIII XCa"/PL la Xa Tfca“ Va Thrombin Fibrinogen Fibrin X Xllla I Crosslinked Fibrin (Blood Clot) Tests of thrombus and haemostasis 历明原层■■■■■■
2025/5/18 9 Tests o f t hr o m bu s an d h ae m o st a s i s 血 栓 和 止 血 检 查
血栓和止血检查 Surface Contact (Intrinsic Pathway) XIla Injury Xla X (Extrinsic Pathway) XCa" TFICA"VIE IXa XCa*/PL Xa Va Thrombin Fibrinogen Fibrin X Crosslinked Fibrin (Blood Clot) Tests of thrombus and haemostasis 回官面■■度加■回酒回面超回卫■■■画题■■面■■面■■■国■■
2025/5/18 10 Tests o f t hr o m bu s an d h ae m o st a s i s 血 栓 和 止 血 检 查