Prevalence of HpV cervical infectionIn women in the world:25-HPV infection prevalence 2-44%-HR HPV prevalence 15.1%202Age (years)-≥ 30 age HR HPV prevalence 5-10%HPV 16 is most common type inwomen with normal cervical cytology But cervical cancer is a rarecomplication of HPV infectionBasemanJG,etal.JClinVirol2005,32S;16-24
Prevalence of HPV cervical infection • In women in the world: –HPV infection prevalence 2-44% –HR HPV prevalence 15.1% – ≥ 30 age HR HPV prevalence 5-10% • HPV 16 is most common type in women with normal cervical cytology • But cervical cancer is a rare complication of HPV infection Baseman JG, et al. J Clin Virol 2005, 32S;16-24
HPV associated Cervical CancerPersistentHPVInfectionTransientInfectionMild cytologicHPVabnormalitiesInitialinfection10-15yProgressionInvasionNormal cervixHPV-infected cervixPrecancerousCancerlesionRegressionClearance80%25201b20(%)rd00oood12HPV15Cancer100500443n095-24o655NEJM348:518-527.200315-50354050-683Age (years)
HPV associated Cervical Cancer NEJM 348:518-527, 2003 80% 10-15 y
Head and neck cancersEpidemiology of HNSCC-50,000newcases/y- 13,000 deaths/ySubdivision by locationNasal Cavity-Nasopharynx-Oral CancerTongueOropharynx- Laryngeal CancerEsophagusLarynx- Nasopharyngeal CancerTracheaHistology types- SCC. Keratinized·Non-keratinized- NPC
Head and neck cancers • Epidemiology of HNSCC – 50,000 new cases/y – 13,000 deaths/y • Subdivision by location – Oral Cancer – Laryngeal Cancer – Nasopharyngeal Cancer • Histology types – SCC • Keratinized • Non-keratinized – NPC
Biological and clinical characteristics of HNScCHNSCC20%HPV80%HPVE6andE7positiveMostlyoropharynx65%highCIN15%lowCINMainlywild-typeTP53FavourableprognosisMany numerical changesFewnumerical changesMainlyaneuploidNeardiploidMainlymutatedTP53Mainlywild-typeTP53Favourableprognosis?LessfavourableprognosisTable1|Different clinicaland biological characteristicsof HPV-negativeand HPV-positiveHNSCCRefsFeatureHPV-negative HNSCCHPV-positiveHNSCCIncidenceDecreasingIncreasing138,13931AetiologyOralsexSmoking,excessivealcoholuseAge138Above60yearsUnder60yearsYesUnknown49,136FieldcancerizationTP53mutationsFrequentInfrequent26,27,140NonePredilection siteOropharynx21,141PoorFavourablePrognosis5,142HNSCC,headandnecksquamouscellcarcinoma;HPV,humanpapillomavirus
Biological and clinical characteristics of HNSCC
Anal cancer~0.16% of men and women born today willhave cancer of the anus, anal canal, oranorectum sometime during their life·Approx5260new cases annuallyin US- 2000 in men and 3260 in w0men· Anal canal lesions may have more aggressivebiology
Anal cancer • ~0.16% of men and women born today will have cancer of the anus, anal canal, or anorectum sometime during their life • Approx 5260 new cases annually in US – 2000 in men and 3260 in women • Anal canal lesions may have more aggressive biology