Molecular diagnosis andmonitoring of HPV infection2
Molecular diagnosis and monitoring of HPV infection 2
HPVPapillomaviridae familyNon-enveloped50-55 nm, icosahedral capsidLCRE6E7Circular genome, dsDNA virus7.905L1>100 HPV types7.0001.00D)-BasedonL1genesequenceE1HPV166.0002.000-HPVsubtypes2-10%3.0006.000-HPVvariants<2%4.000L2E2E4
HPV • Papillomaviridae family • Non-enveloped • 50-55 nm, icosahedral capsid • Circular genome, dsDNA virus • >100 HPV types – Based on L1 gene sequence – HPV subtypes 2-10% – HPV variants <2%
Mucosal HPV typesOncogenityHPV typesHigh risk HPV types16, 18,31,33,3539, 45, 52, 56, 58, 5967, 68, 70LowriskHPVtypes6,11,40,42,43,4454, 61, 70, 72, 74, 81,83, 84Probable high risk26, 51, 53, 56, 66, 6982types
Oncogenity HPV types High risk HPV types 16, 18, 31, 33, 35, 39, 45, 52, 56, 58, 59, 67, 68, 70 Low risk HPV types 6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 74, 81, 83, 84 Probable high risk types 26, 51, 53, 56, 66, 69, 82 Mucosal HPV types
Productive infection- HPV replicationKeratinocytesrelease2N0Stratumcorneum一StratumgranulosumStratumspinosum+E1,E2Basalcells20-100HPVDNA/cell
Stratum corneum Stratum granulosum Stratum spinosum Basal cells E 1, E2, E4, E5,E6,E7 E1, E2 20-100 HPV DNA/cell E4, L 1, L 2 >1000 HPV DNA /cell Keratinocytes release Productive infection- HPV replication
HPV associated cancers12,000FemalesMales10,000asie8,0006.0004,0002,000PenisCervixVulvaVaginaAnusHeadandNeck*CancerSite
HPV associated cancers