Virulence factors Elastase: cause damage to blood vessel walls, resulting in hemorrhagic lesions (ecthyma gangrenosum) Associated with disseminated Pseudomonas infections Pyocyanin: mediates tissue damage through toxic oxygen radicals BIOL 533 7 Lecture 13
BIOL 533 7 Lecture 13 Virulence Factors • Elastase: cause damage to blood vessel walls, resulting in hemorrhagic lesions (ecthyma gangrenosum) – Associated with disseminated Pseudomonas infections • Pyocyanin: mediates tissue damage through toxic oxygen radicals
Toxins EXotoxin A: mechaism like diphtheria toxin but much milder Two toxins are structurally and immunologically different Exoenzyme S: also ADP-ribosyltrnasferaser but heat stabile Found in 33. 3 clinical isolates BIOL 533 Lecture 13
BIOL 533 8 Lecture 13 Toxins • Exotoxin A: mechaism like diphtheria toxin, but much milder – Two toxins are structurally and immunologically different • Exoenzyme S: also ADP-ribosyltrnasferase, but heat stabile – Found in 33.3% clinical isolates