上海交通大学：《微生物学 Microbiology》课程教学资源（双语课件）Lecture 9.2 Essentials of Virology（Viral Replication 病毒复制、Viral Diversity）

9.5 Virus Multiplication:Attachment and Penetration Example:T4 phage (a)Unattached virion. (b)Attachment to the (c)Contact of cell wall by the wall by the long tail tail pins尾针. fibers尾丝interacting with core polysaccharide. (d)Contraction of the tail sheath尾鞘and injection of the DNA. Lipopolysaccharide layer(outer membrane) Peptidoglycan Cytoplasmic membrane

9.5 Virus Multiplication: Attachment and Penetration (a) Unattached virion. (b) Attachment to the wall by the long tail fibers尾丝 interacting with core polysaccharide. (c) Contact of cell wall by the tail pins尾针. (d) Contraction of the tail sheath 尾鞘and injection of the DNA. Example: T4 phage

Figure 9.10 (a) (b) (c) Tail fibers Tail pins Outer 致级核攻攻及及员级级级级级领级 membrane Tail Peptidoglycan lysozyme Cytoplasmic membrane Cytoplasm T4 genome 2012 Pearson Education,Inc

Figure 9.10 Tail fibers Tail pins Outer membrane Peptidoglycan Cytoplasmic membrane Cytoplasm Tail lysozyme T4 genome © 2012 Pearson Education, Inc

START RECEPTORS LIGANDS OR DOCKING PROTEINS 季 PENETRATION HHHH-HH-HHH DOCKING/ADSORPTION herpesviruses,paramyxoviruses,HIV Attachment and penetration of Animal virus

Attachment and penetration of Animal virus

上游充通大学 SHANGHAI JIAO TONG UNIVERSITY Uptake of an enveloped virion by an animal cell (a)Direct penetration by naked viruses Caps ol-ol-d b)Enveloped virs 元0 c)Entry of enveloped virus by endocytosis ⑨o@@d. Figure 18.4 Animal Virus Entry.Mechanisms of animal virus attachment and entry into host cells.See text for description of the three entry modes

Chen Feng, Shanghai Jiao Tong University Uptake of an enveloped virion by an animal cell

上游充通大学 SHANGHAI JIAO TONG UNIVERSITY 9.6 Virus Multiplication:Production of Virual Nucleic Acid and Protein Viruses have different types of genomes,including double-stranded/single-stranded DNA and double- stranded/single-stranded RNA. Chen Feng,Shanghai Jiao Tong University

Chen Feng, Shanghai Jiao Tong University 9.6 Virus Multiplication: Production of Virual Nucleic Acid and Protein Viruses have different types of genomes, including double-stranded/ single-stranded DNA and double￾stranded/ single-stranded RNA