Antibiotics One of the most significant discovery of modern medicine Saved countless lives
Antibiotics One of the most significant discovery of modern medicine Saved countless lives
Terms and definition Antimicrobial spectrum ·Bactericidal-MBc ·bacteriostatic-MlC Therapeutic index:LD30/ED50 Post-antibiotic effect
Terms and definition • Antimicrobial spectrum • Bactericidal-MBC • bacteriostatic-MIC • Therapeutic index: LD50 /ED50 • Post-antibiotic effect
Concept 1:Antimicrobial spectrum Antimicrobial spectrum: the species of microorganisms that a drug can inhibit or kill. For example, penicillin: Gram-positive bacteria Leptospira（钩端螺旋体) Actinomycetes(放线菌)
Concept 1: Antimicrobial spectrum Antimicrobial spectrum: the species of microorganisms that a drug can inhibit or kill. For example, penicillin: Gram-positive bacteria Leptospira（钩端螺旋体） Actinomycetes（放线菌）
Antimicrobial spectrum ◆Narrow spectrum The agents act against a single or limited group of microorganisms (isoniazid:mycobacteria ◆Broad spectrum The agent affect a wide variety of microbial species (tetracycline)
Antimicrobial spectrum Narrow spectrum The agents act against a single or limited group of microorganisms (isoniazid: mycobacteria ) Broad spectrum The agent affect a wide variety of microbial species (tetracycline)
Concept 2: Bacteriostatic vs.Bactericide √Bacteriostatic(抑菌药)： Arrest the growth or replication of the microorganism. For example:Sulfanilamide √Bactericide(杀菌药)： Agents which can kill the microorganisms
Concept 2: Bacteriostatic vs. Bactericide Bacteriostatic （抑菌药）: Arrest the growth or replication of the microorganism. For example: Sulfanilamide Bactericide （杀菌药）: Agents which can kill the microorganisms