Proteoglycans (PG) 1μm aggrecan aggregate High molecular weight complexes of GAG core protein covalently bind with (aggrecan) core proteins; Structure link protein hyaluronan molecule keratan sulfate chondroitin sulfate This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Proteoglycans (PG) Sythesized and assembled in ER 1)Polysaccharides are assembled to core protein in ER lumen by glycosyltransferases,which in turn add monosaccharide to the specific tetrasaccharide structure on serine; 2)Polymorphology of amino acid sequence and sugar chain; 3)Some PG are integrated members of plasma membrane (Syndecan,蛋白多糖). This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Function of GAG and PG 1.Make the tissues have flexibility and resistance to stress; 2.Selective permeability of the material transport (glomerulus,.肾小球)； 3.Proteoglycans in the cornea()are translucent; 4.Anticoagulant effect; 5.Signal transition; 6.Invovled in tissue aging. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
GAG PG and disease 1.Abnormal degradation-abnormal accumulation- mucopolysaccharidoses(黏多糖贮积病)； 2.Change of content ratio-lipid deposition-atherosclerosis (动脉粥样硬化)； 3.Secretion increase and level of sulfate reduced-promote tumor cell proliferation and migration -tumor proliferation, invasion,and metastasis. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
2.Collagen and elastin Collagen is the skeleton of ECM The most abundant protein in human. ■ Structure:Triple helix of 3 a-polypeptide strands,the sequence is repeate of Gly-X-Y; There're many types of a strands with different kinds of combination style. Pri-peptide-remove signal peptide-add prepeptide on each ends.—Hydroxylation-—cross link at C terminal(procollagen)-secreted outside-remove prepeptide-self-assembly-mature collagen. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information