Organic Chemistry Organic and Biological Chemistry in Modern Medicine Coronary artery disease(CAD)is directly correlated with blood cholesterol leě#病 75%of blood cholesterol (1000 mg a day)is biosynthesized Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels他汀类药物 他汀类降血脂药) 3-Hydroxy-3-methylglutaryI coenzyme A(HMG-CoA)to mevalonate conversion3-羟基-3甲基戊二酰辅酶A Crucial step in biosynthesis of cholesterol Atorvastatin (Lipitor)inactivates enzyme that catalyzes HMG-CoA to mevalonate conversion ▣阿托伐他汀
Organic and Biological Chemistry in Modern Medicine ◆Coronary artery disease (CAD) is directly correlated with blood cholesterol levels ▪ 75% of blood cholesterol (1000 mg a day) is biosynthesized ▪Drugs known as Statins reduce the risk of CAD by lowering blood cholesterol levels ◆3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonate conversion ▪ Crucial step in biosynthesis of cholesterol ▪ Atorvastatin (Lipitor) inactivates enzyme that catalyzes HMG-CoA to mevalonate conversion ▪ 阿托伐他汀 Organic Chemistry 冠状动脉疾病 他汀类药物 3-羟基-3甲基戊二酰辅酶A 他汀类降血脂药）
H3C OH H3C OH CH3 02C SCoA OH HO 3-Hydroxy-3-methyl- Mevalonate Cholesterol glutaryl coenzyme A (HMG-CoA) H K692 K691 HO. c02 Lo6 OH D6 H R556 R590 3.2 CH3 27 H752 S684 L562 K735 CH3 L853 V683 L967 1850 R508 Atorvastatin (Lipitor)
The future mission of Chemistry? Angewandte GDCh Ajoumal of the Gesellschaf Chemie Deutscher Chemiker Explore this journal Volume 54,Issue 11 Essay March 9,2015 Pages3196-3209 Reinventing Chemistry The chemistry must expand Angewandte Prof.George M.Whitesides First published:12 February 2015 Full publicatior its mission from "molecules," DOI:10.1002/anie.201410884 View/save citation Cited by:25 articles Citation tool to "everything that involves 4-4-1 molecules." View issue TOC Special Issue: 150 Years of BASF Abstract Chemistry is in a period of change,from an era focused on molecules and reactions,to one in which manipulations of CHANGE systems of molecules and reactions will be essential parts controlling larger systems.This Essay traces paths from the past to possible futures. The End of One Era and the Beginning of Another --Whitesides,G.M.(2015),Reinventing Chemistry.Angew.Chem.Int.Ed.,54:3196-3209. (德国应用化学)
The Future Mission of Chemistry？ ---Whitesides, G. M. (2015), Reinventing Chemistry. Angew. Chem. Int. Ed., 54: 3196–3209. （德国应用化学） The chemistry must expand its mission from “molecules,” to “everything that involves molecules