上降充通大￥ SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 major determinants of myocardial oxygen consumption: >myocardial basic metabolism heart rate contractility ventricular volume ventricular pressure >wall tension ejection time blood pressure (peripheral resistance)
major determinants of myocardial oxygen consumption: myocardial basic metabolism heart rate contractility wall tension ejection time blood pressure (peripheral resistance) ventricular volume ventricular pressure
上游充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 The mechanism of antianginal drugs O2 increase supply and/or lower demand Myocardial O2 supply:Coronary blood flow, regional flow distribution Myocarial O2-demand:amount of energy required to support the work of the heart ■ Cardiac work influenced by:heart rate, heart contractility,myocardial wall tension
The mechanism of antianginal drugs O2 increase supply and/or lower demand Myocardial O2 supply: Coronary blood flow, regional flow distribution Myocarial O2 –demand: amount of energy required to support the work of the heart Cardiac work influenced by: heart rate, heart contractility, myocardial wall tension