定义菌血症其他真菌败血症感染SIRS创伤寄生虫病毒烧伤其他胰腺炎全身炎症反应综合征与感染、非感染的关系
定义 菌血症 其他 真菌 感 染 败血症 SIRS 其他 寄生虫 感 染 败血症 SIRS 创伤 病毒 其他 烧伤 胰腺炎 全身炎症反应综合征与感染、非感染的关系
定义(SSC2012)脓毒症(Sepsis),即脓毒血症由感染因素引起的损害性全身炎症反应综合征(SIRS),严重时可导致器官功能障碍综合征和(或)循环衰竭。>严重脓毒症(Severe sepsis)脓毒症合并脓毒症引起的器官功能障碍或者组织灌注不足脓毒症休克(Septic shock)由脓毒症引起的,尽管充分补液但仍存在持续性低血压
定义(SSC 2012) 脓毒症(S i ) 即脓毒血症 定义(SSC 2012) ¾ 脓毒症(Sepsis),即脓毒血症 由感染因素引起的损害性全身炎症反应综合征 (SIRS),严重时可导致器官功能障碍综合征和 (或)循环衰竭。 ¾ 严重脓毒症(Severe sepsis Severe sepsis) 脓毒症合并脓毒症引起的器官功能障碍或者组 织灌注不足 ¾ 脓毒症休克(Septic shock) 由脓毒症引起的,尽管充分补液但仍存在持续 性低血压
TABLE1.DiagnosticCriteriaforSepsisInfection,documented orsuspected,andsome ofthefollowing:GeneralvariablesFever(38.3°C)Hypothermia(coretemperature<36°C)Heart rate>90/min-1 or more than two sD above the normal valuefor ageTachypneaAlteredmental statusSignificantedemaorpositivefluidbalance20mL/kgover24hr)Hyperglycemia(plasmaglucose>140mg/dLor7.7mmol/L)intheabsenceofdiabetesInflammatoryvariablesLeukocytosis(WBCcount>12,000μL-f)Leukopenia(WBCcount<4000uL-)Normal WBCcountwithgreaterthan10%immatureformsPlasma C-reactiveproteinmorethantwosDabovethenormal valuePlasma procalcitonin morethantwo sD abovethe normalvalue
TABLE1.DiagnosticCriteriaforSepsisHemodynamicvariablesArterialhypotension(SBP<90mmHgMAP<70mmHg.oranSBPdecrease>40mmHginadultsorlessthantwosDbelownormalforage)OrgandysfunctionvariablesArterialhypoxemia(Pao,/Fio,<300)Acuteoliguria(urineoutput<0.5mL/kg/hrforatleast2hrsdespiteadequatefluid resuscitation)Creatinineincrease>0.5mg/dLor44.2μmol/LCoagulationabnormalities(INR>1.5oraPTT>60s)lleus(absentbowelsounds)Thrombocytopenia(plateletcount<100,000μL-1)Hyperbilirubinemia(plasmatotalbilirubin>4mg/dLor70μmol/L)TissueperfusionvariablesHyperlactatemia1mmol/L)Decreasedcapillaryrefill ormottling
TABLE2.SevereSepsisSevere sepsis definition=sepsis-inducedtissuehypoperfusion ororgan dysfunction(any ofthefollowingthoughttobeduetotheinfection)Sepsis-inducedhypotensionLactateaboveupperlimitslaboratorynormalUrineoutput<o.5mL/kg/hrformorethan2hrsdespiteadequatefluidresuscitationAcutelung injurywithPao,/Fio,<250 in theabsenceofpneumoniaas infectionsourceAcute lung injurywithPao,/Fio,<200 inthepresenceof pneumoniaas infection sourceCreatinine>2.0mg/dL(176.8μmol/L)Bilirubin>2mg/dL(34.2umol/L)Plateletcount<100,000μlCoagulopathy(intemationalnormalizedratio>1.5)