重蹇等科大学 ongging Medical University DISEASES OF URINARY SYSTEM Depart.of pathol.CQMU
DISEASES OF URINARY SYSTEM Depart. of pathol.CQMU
倒重麦普种大号 gqing Med山eal Univers Glomerulonephritis-GN Secondary GN-caused by a variety of factors and in the course of a number of systemic diseases. SLE(systemic lupus erythematosus), hypertention,polyarteritis nodosa,diabetes. Primary GN-kedney is the only or the predominant organ invulved
Glomerulonephritis-GN Secondary GN—caused by a variety of factors and in the course of a number of systemic diseases . SLE(systemic lupus erythematosus), hypertention, polyarteritis nodosa, diabetes. Primary GN - kedney is the only or the predominant organ invulved
1.Pathogenesis of Glomerular Injury Antibody-Mediated Injury 1)In situ immune complex deposition a.anti-GBM Nephritis (Ab react directly with GBM Ag or planted Ag) b.Heymann Nephritis (Ab cross-react with the visceral epithelial cells and blush border Ag) 2)Circulating immune complex deposition Cell-Mediated immune Injury Macrophages,T cells Activation of Complement Pathway A common pathway of glomerular injury
1.Pathogenesis of Glomerular Injury Antibody-Mediated Injury 1)In situ immune complex deposition a. anti-GBM Nephritis ( Ab react directly with GBM Ag or planted Ag) b. Heymann Nephritis (Ab cross-react with the visceral epithelial cells and blush border Ag) 2)Circulating immune complex deposition Cell-Mediated immune Injury Macrophages, T cells Activation of Complement Pathway A common pathway of glomerular injury
重蹇暗科大图 2.Mechanisms and Mediators of glomerular damige Complement triggers attracts IC-complement cascade neutrophil Nephritic factors: Polymorphonuclear leukocytes Clotting factors:Fibrin,platelets C3 and Fc receptors
2.Mechanisms and Mediators of glomerular damige Complement : triggers attracts IC- complement cascade - neutrophil Nephritic factors: Polymorphonuclear leukocytes : Clotting factors: Fibrin , platelets C3 and Fc receptors
重蹇等科大学 3.Clinical Manifestations 1)acute nephritic syndrome:Hematuria. azotemia,red blood cell casts,variable proteinuria (<1gm/day),oliguria,edema,and hypertension 2)nephrotic syndrome:>3.5 gm/day proteinuria, hypoalbuminemia,hyperlipidemia,lipiduria 3)Asymptomatic hematuria or proteinuria; Glomerular hematuria:subnephrotic proteinuria
3.Clinical Manifestations 1)acute nephritic syndrome: Hematuria. azotemia, red blood cell casts, variable proteinuria (<1gm/day), oliguria, edema, and hypertension 2)nephrotic syndrome: >3.5 gm/day proteinuria, hypoalbuminemia, hyperlipidemia, lipiduria 3)Asymptomatic hematuria or proteinuria: Glomerular hematuria: subnephrotic proteinuria