圈重走普科大子 hongqing Medicol University Cardiovascular System Disease Depart.of Pathol.CQMU
Atherosclerosis (ATH) 1.Definition Atherosclerosis is a disease of large and medium sized arteries,characterised by lipid deposition and fibrosis
Atherosclerosis (ATH) 1.Definition Atherosclerosis is a disease of arteries, characterised by
2.Aetiology Risk factors ●Hyperlipidemia LDL (Low density lipoprotein) HDL (High density lipoprotein) ●Hypertension ● Smoking ● Diabetes ● coexistence LDL,obesity, hypertension hyperlipidemia Others Age Genetic factors
2.Aetiology Risk factors l Hyperlipidemia LDL (Low density lipoprotein)↑ HDL (High density lipoprotein)↓ l Hypertension l Smoking l Diabetes l coexistence LDL , obesity, hypertension ,hyperlipidemia l Others : Age Genetic factors
重废骑大净 3.Pathogenesis Most theories invoke some damage to endothelium or underlying smooth muscle blood lipid 1 endothelial permeability increased
3. Pathogenesis Most theories invoke some damage to endothelium or underlying smooth muscle . blood lipid ↑ endothelial permeability increased
重蹇等科大学 thongqing Medicol University smooth muscle migration from media to intima,followed by proliferation. Monocytes phagocytize lipid and Smooth muscle cells also phogocytosis (lipid)-foam cells (the fatty streak) Smooth muscle cells synthesize extracellular matrix (the fibrous plaque) the lipid release by necrotic foam cells mixed with necrotic tissues (atheromatous plaque)
smooth muscle migration from media to intima, followed by proliferation. Monocytes phagocytize lipid and Smooth muscle cells also phogocytosis (lipid)-foam cells (the fatty streak) Smooth muscle cells synthesize extracellular matrix (the fibrous plaque) the lipid release by necrotic foam cells mixed with necrotic tissues (atheromatous plaque)