Classification, and Antigenic Types Toxigenic strains are lysogenic for one of afamily of corynebacteriophages that carry thestructural gene for diphtheria toxin, tox Corynebacterium diphtheriae is classified into Biotypes (mitis, intermedius, and gravis according to colony morphologyLysotypes-based upon corynebacteriophage sensitivitySHIHEZI UNIVERSITY
Classification, and Antigenic Types Toxigenic strains are lysogenic for one of a family of corynebacteriophages that carry the structural gene for diphtheria toxin, tox Corynebacterium diphtheriae is classified into Biotypes (mitis, intermedius, and gravis) according to colony morphology Lysotypes based upon corynebacteriophage sensitivity SHIHEZI UNIVERSITY
Pathogenesis Colonize at the upper respiratory tract(nasopharynxToxigenic strains secrete a potent exotoxin which maycause diphtheriaDoes not produce a systemic infection Systemic toxemia may be involved A pseudomembrane forms locally+composed of fibrin, bacteria, and inflammatory cells+ which can cause chockingSHIHEZI UNIVERSITY
Pathogenesis Colonize at the upper respiratory tract (nasopharynx) Toxigenic strains secrete a potent exotoxin which may cause diphtheria Does not produce a systemic infection Systemic toxemia may be involved A pseudomembrane forms locally composed of fibrin, bacteria, and inflammatory cells which can cause chocking SHIHEZI UNIVERSITY