Apoptosis and Diseases The Nobel Prize in Physiology or Medicine 2002 for their discoveries concerning 'genetic regulation of organ development and programmed cell death 囻厦 Sydney brenner H. Robert Horvitz John E Sulston 0 1/3 of the prize 1/3 of the prize 1/3 of the prize United Kingdon USA United Kingdom The Molecular Massachusetts The Wellcome Trust Sciences InstituteInstitute of Sanger Institute Berkeley, CA, USA Technology(MIT) Cambridge, United Cambridge, MA, Kingd。m USA
Apoptosis and Diseases
1. Concept 2. Apoptotic process and changes 3. Key molecules and Major pathways 4. Techniques to detect apoptosis 5. Apoptosis-related diseases Insufficient apoptosis in diseases Excessive apoptosis in diseases Coexistence of insufficient and excessive apoptosis in diseases 6. Principles of treatment
1. Concept 2. Apoptotic process and changes 3. Key molecules and Major pathways 4. Techniques to detect apoptosis 5. Apoptosis-related diseases • Insufficient apoptosis in diseases • Excessive apoptosis in diseases • Coexistence of insufficient and excessive apoptosis in diseases 6. Principles of treatment
What is Apoptosis t apoptosis refers to the process in which the dying procedures_that have been in advance deposited in cell are triggered by various causes from in vitro and in vivo, and eventually cause cell death + Programmed cell death (PCD) Final stage of apoptosis White blood cell 器·额 a CSgO
What is Apoptosis ? Apoptosis refers to the process in which the dying procedures that have been in advance deposited in cell are triggered by various causes from in vitro and in vivo, and eventually cause cell death. Programmed cell death（PCD）
Causes and Process of Apoptosis Inhibitory Factors Stimulatory Factors Physiological Initiation Physiological GFS, estrogen, etc, Fasl. Pathological Pathological virus: chemicals, etc glutamate, free radicals; therapeutics Regulation Conserved Execution growth factor Glucocorticoids activat radiation essential ceptor attacks target Phagocytosis Unknown Unknown Requires po3 trigger Initiated by death
Initiation Regulation Execution Phagocytosis Physiological: GFs, estrogen, etc; Pathological: virus; chemicals, etc. Inhibitory Factors Stimulatory Factors Physiological: FasL; Pathological: glutamate, free radicals; therapeutics. Conserved Causes and Process of Apoptosis
Apoptotic changes Morphological changes in apoptosis ---Biochemical Changes in Apoptosis
Apoptotic changes ---Morphological changes in apoptosis ---Biochemical Changes in Apoptosis