Reinforcement Learning and Immune Memory -0-一一--一一--一一--一一--一一 --一一-一--- Repeated exposure to an antigen throughout a lifetime Primary,secondary immune responses Remembers encounters No need to start from scratch ◆Memory cells 张Associative memory CEC 2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems Reinforcement Learning and Immune Memory Repeated exposure to an antigen throughout a lifetime Primary, secondary immune responses Remembers encounters No need to start from scratch Memory cells Associative memory
Learning (2) -一一--一一--一一--- Primary Response Secondary Response Cross-Reactive Response Lag Lag Response Response to Lag H to Agi Agi +Ag3 Response to Agi Response to Ag2 仓 Time Antigen Ag Antigens Antigen Agi,Ag2 Agi Ags CEC 2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems Learning (2) Antigen Ag1 Antigens Ag1, Ag2 Primary Response Secondary Response Lag Response to Ag1 Antibody Concentration Time Lag Response to Ag2 Response to Ag1 ... ... Cross-Reactive Response ... ... Antigen Ag1 + Ag3 Response to Ag1 + Ag3 Lag
Immune Network Theory --一一--一一--一一--一一---一--一一----- Idiotypic network (Jerne,1974) B cells co-stimulate each other Treat each other a bit like antigens Creates an immunological memory Suppression Negative response Paratope Idiotope Antibody Activation Positive response CEC 2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems Immune Network Theory Idiotypic network (Jerne, 1974) B cells co-stimulate each other Treat each other a bit like antigens Creates an immunological memory 1 2 3 Ag Activation Positive response Suppression Negative response Antibody Paratope Idiotope
Immune Network Theory(2) Antigen epitope B Cell 2 supression stimulation Idiclope 2 B Cell 1 anti body 2 Patalope 2 B Cell 3 antibody 1 Patatope 1 anti body Ldiotope 3 antibody 3 Patatope 3 B Cell 4 CEC 2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems Immune Network Theory(2)