Immune Pattern Recognition -·---·-BC求or Antibody B-cell Receptors(Ab) Epitopes Antigen B-cell 米 The immune recognition is based on the complementarity between the binding region of the receptor and a portion of the antigen called epitope. Antibodies present a single type of receptor,antigens 米 might present several epitopes. This means that different antibodies can recognize a single antigen CEC 2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems Immune Pattern Recognition The immune recognition is based on the complementarity between the binding region of the receptor and a portion of the antigen called epitope. Antibodies present a single type of receptor, antigens might present several epitopes. This means that different antibodies can recognize a single antigen B-cell BCR or Antibody Epitopes B-cell Receptors (Ab) Antigen
Antibodies --一一--一一-- 一一--一一------一一---一--一一--一--- 当id-r6 Antigen binding sites 0 Gene rearrangement 小 v 的-rS C CW Rearranged DNA Fab C Fab 0 Transcription RNA 0 Splicing CH CH Fc mRNA 0 Translation Heavy chain of an immunoglobulin Antibody Molecule Antibody Production CEC 2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems Antibodies Antigen binding sites VH VL CH CH VL CL CH VH CH CL Fc Fab Fab Antibody Molecule ... ... ... V V D D J J C Gene rearrangement Rearranged DNA V D J C Transcription RNA V D J C Splicing mRNA V D J C Translation Heavy chain of an immunoglobulin Antibody Production
Clonal Selection 一一--一一--一一 O Clonal deletion (negative selection) Self-antigen Proliferation (Cloning) O 刀 Antibody Selection Memory cells 0□0"， O Differentiation Plasma cells Foreign antigens Or Self-antigen Clonal deletion (negative selection) CEC2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems Clonal Selection Foreign antigens Proliferation (Cloning) Differentiation Plasma cells Memory cells Selection M M Antibody Self-antigen Self-antigen Clonal deletion (negative selection) Clonal deletion (negative selection)
T-cells -----------一一--一一--一一--一一---- -一一--一一--一一-- Regulation of other cells *Active in the immune response ◆Helper T-cells ◆Killer T-cells TCR MHC-lI Protein APC Peptide T-cell MHC/peptide complex CEC2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems T-cells Regulation of other cells Active in the immune response Helper T-cells Killer T-cells T-cell TCR
Main Properties of Clonal Selection (Burnet,1978) --一一--一一 *Elimination of self antigens Proliferation and differentiation on contact of matu lymphocytes with antigen Restriction of one pattern to one differentiated cell ar retention of that pattern by clonal descendants; 米Generation of new random genetic change subsequently expressed as diverse antibody patterns a form of accelerated somatic mutation CEC 2001 Artificial Immune Systems
CEC 2001 Artificial Immune Systems Main Properties of Clonal Selection (Burnet, 1978) Elimination of self antigens Proliferation and differentiation on contact of mature lymphocytes with antigen Restriction of one pattern to one differentiated cell and retention of that pattern by clonal descendants; Generation of new random genetic changes, subsequently expressed as diverse antibody patterns by a form of accelerated somatic mutation