Herpes comes from Greek word“ herpes (to creep or crawl) Herpesviruses Dongli pan Department of Medical Microbiology and Parasitology Zhejiang University School of Medicine pandongli@zju. edu.cl
Herpesviruses Dongli Pan Department of Medical Microbiology and Parasitology Zhejiang University School of Medicine pandongli@zju.edu.cn Herpes comes from Greek word “herpein” （to creep or crawl）
Learning Objectives Be familiarized with all human herpesviruses and their associated diseases Know herpesvirus replication cycle and latency reactivation cycle Know the infection cycles and pathogenesis of Hsv-1 HSV-2 VZV HCMV EBV Know anti-herpesvirus drugs and their mechanisms of action
Learning Objectives • Be familiarized with all human herpesviruses and their associated diseases. • Know herpesvirus replication cycle and latencyreactivation cycle. • Know the infection cycles and pathogenesis of HSV-1, HSV-2, VZV, HCMV, EBV. • Know anti-herpesvirus drugs and their mechanisms of action
Baltimore classification DNA viruses RNA viruses Group I Group Il Group Ill Group IV Group v GroupⅥl GroupⅦl DNA(+/-) DNA什+ RNA(+/-) RNA(+) RNA(-) RNA(+) DNA(+/-) Reverse transcription RNA(-) Reverse DNA(+/-) transcription mRNA proteins Fields virology, 6th edition
Fields Virology, 6th edition DNA viruses RNA viruses Baltimore classification
Classification of herpesviruses Family Herpesviridae Subfamily Alphaherpesvirinae Species HSV-1 HSV-2 VZ∨ (animal viruses Betaherpesvirinae HCMV HHV-6A HHV-6B HHV-7 (animal viruses) Gammaherpesvirinae EBV KSHV (animal viruses There are 9 currently known human herpesviruses
Herpesviridae Alphaherpesvirinae HSV-1 HSV-2 VZV ..…. (animal viruses) Betaherpesvirinae HCMV HHV-6A HHV-6B HHV-7 …...(animal viruses) Gammaherpesvirinae EBV KSHV …...(animal viruses) Classification of herpesviruses There are 9 currently known human herpesviruses Family Subfamily Species
Size of herpesviruses Plant Animal Bacteria Viruses Ribosomes Proteins Small Atoms ells ⊥ I hl hui u l hll hlll」 Meters 10-2 105 107 10 (1cm) (1mm) (1A) Light microscope Electron microscope X ra NMR X Herpesvirus Ribosomes 200nm) (20nm) Poliovirus (30 nm) Principle of virology
Size of herpesviruses Principle of Virology