Herpesvirus structural components Spherical, 120-260 nm in diameter dsdNa genome(124-295kb), encoding 70-200 protein Capsids have icosahedral symmetry There is a tegument and an envelope Envelope proteins Envelope dSDNA Tegument UTUTU Capsid
Spherical, 120-260 nm in diameter dsDNA genome (124-295kb)，encoding 70-200 protein Capsids have icosahedral symmetry There is a tegument and an envelope Herpesvirus structural components Envelope proteins Envelope dsDNA Tegument Capsid
Types of herpesvirus infections Herpesviruses can typically undergo the following three types of infections a. Primary infection viral replication and cytolysis b Latent infection No viral replication dna genome remains in host for the life time of host C. Recurrent infection: viral replication after reactivation HSV-1, HSV-2, Vzv, HCMV can also undergo congenital infections(mother to child transmission during pregnancy or birth) HHV-6A and HHv-6b can undergo integrated infection
• Herpesviruses can typically undergo the following three types of infections: a. Primary infection: viral replication and cytolysis b. Latent infection: No viral replication, DNA genome remains in host for the life time of host c. Recurrent infection: viral replication after reactivation • HSV-1, HSV-2, VZV, HCMV can also undergo congenital infections (mother to child transmission during pregnancy or birth) • HHV-6A and HHV-6B can undergo integrated infection. Types of herpesvirus infections
Biological Cycle of Herpesviruses (Including congenital infection) Primary Infection Establish latency Productive(lyti Latent infection infection Reactivation tablish later Recurrent Infection
Biological Cycle of Herpesviruses Primary Infection Productive (lytic) infection Latent infection Recurrent Infection (Including congenital infection) Establish latency
HSV replication cycle ③。。 protein (Vhs) sEeree Immediate. san s回八 concatemeric DNA heen s回 oteins a p-O Principles of virology
HSV replication cycle Principles of Virology
Human herpesviruses Subfamily Virus Primary Target Site of Means of Spread Diseases Species Cell Latency Mucoepithelial cells Neuron Close contact Cold sores, gingivostomatitis HSV-1 Herpetic keratitis, Encephalitis HH-1) HSV-2 Mucoepithelial cells Neuron Close contact Genital herpes herpesviridae (HHV-2 sexual transmission Mucoepithelial cellsNeuron Respiratory and Chicken pox, Shingles (H3) close contact HcM∨ Monocyte, Monocyte, Close contact Infectious mononucleosis. Retinitis (HHV-5)ymphocyte, andlymphocyte, transfusions, tissue Diseases for newborn and epithelial cells and transplant, congenital immunocompromised herpesviridae HHV-6A T cells and? T cells and? Respiratory and Roseola. Others? and 6B close contact HHV-7 T cells and T cells and?? Roseola. others? EBV B cell and epithelial B cell Saliva( Kissing Infectious mononucleosis HHV-4)cell disease nasopharyngeal carcinoma, Burkitt's lymphoma herpesviridae malignant lymphoma KSHV Lymphocyte and B cell Close contact Kaposis sarcoma (HHV-8) other cell (sexual), saliva? Wikipedia. org
Subfamily Virus Species Primary Target Cell Site of Latency Means of Spread Diseases α herpesvirinae HSV-1 (HHV-1) Mucoepithelial cells Neuron Close contact Cold sores, gingivostomatitis Herpetic keratitis, Encephalitis HSV-2 (HHV-2) Mucoepithelial cells Neuron Close contact ( sexual transmission) Genital herpes VZV (HHV-3) Mucoepithelial cells Neuron Respiratory and close contact Chicken pox, Shingles β herpesvirinae HCMV (HHV-5) Monocyte, lymphocyte, and epithelial cells Monocyte, lymphocyte, and ? Close contact transfusions, tissue transplant, congenital Infectious mononucleosis, Retinitis, Diseases for newborn and immunocompromised HHV-6A and 6B T cells and ? T cells and ? Respiratory and close contact Roseola, Others? HHV-7 T cells and ? T cells and ? ? Roseola, Others? γ herpesvirinae EBV (HHV-4) B cell and epithelial cell B cell Saliva ( Kissing disease ) Infectious mononucleosis, nasopharyngeal carcinoma, Burkitt’s lymphoma malignant lymphoma KSHV (HHV-8) Lymphocyte and other cell B cell Close contact (sexual), saliva? Kaposi’s sarcoma Human herpesviruses Wikipedia.org